Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 7/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006573 | 0.89 | ATR (0.59) | ATR | |
| SCHEMBL4009811 | 0.85 | MCHR1 (0.49) | ATRADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL3927916 | 0.85 | ATR (0.48) | ATRADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL4297778 | 0.82 | ATR (0.58) | ATRADORA2AMAP3K11 | |
| SCHEMBL4009857 | 0.82 | MCHR1 (0.51) | ATRADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL4004985 | 0.81 | ATR (0.47) | ATRADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL4008321 | 0.81 | ATR (0.55) | ATRADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL3928126 | 0.77 | MCHR1 (0.47) | ADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL4011105 | 0.75 | MCHR1 (0.52) | ATRADORA2AADORA1MCHR1MAP3K11 | |
| SCHEMBL220877 | 0.74 | NOS3 (0.61) | ADORA2AADORA1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |