Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 6/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 3/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491365 | 0.85 | DPP4 (0.35) | SPRDPP4KCNH2DPP7PPARG | |
| SCHEMBL5225488 | 0.83 | TP53 (0.38) | SPRPPARGMAPTLMNA | |
| SCHEMBL2186866 | 0.82 | NR2E1 (0.47) | MAPTLMNA | |
| SCHEMBL2185602 | 0.81 | KDM4E (0.45) | SPRHSD11B1 | |
| SCHEMBL2186066 | 0.79 | LMNA (0.45) | MAPTHSD17B10LMNA | |
| SCHEMBL3063005 | 0.74 | SPR (0.39) | SPRHSD11B1 | |
| SCHEMBL18711312 | 0.73 | SPR (0.47) | SPRTRPC3TRPC6HSD11B1PDE4B | |
| SCHEMBL28020356 | 0.71 | SPR (0.44) | SPR | |
| SCHEMBL18701897 | 0.70 | SPR (0.45) | SPRKCNH2PPARGTRPC3TRPC6 | |
| SCHEMBL3281807 | 0.70 | CYP1A2 (0.46) | MAPTHSD17B10PDE5APDE4APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090304632-A1 | HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090304632-A1 | HETEROCYCLIC NF-kB INHIBITORS | NFKBIA, NFKB2, IKBKB | SPR 4230/4885DPP4 4559/4885KCNH2 1008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.