Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | SPR | P35270 | 12/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186866 | 0.82 | NR2E1 (0.47) | KDM4EALDH1A1 | |
| SCHEMBL4298330 | 0.81 | SPR (0.45) | SPRHSD11B1 | |
| SCHEMBL2213735 | 0.77 | KDM4E (0.52) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2188470 | 0.77 | KDM4E (0.51) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2186066 | 0.77 | LMNA (0.45) | ALDH1A1POLB | |
| SCHEMBL2188126 | 0.76 | ALDH1A1 (0.50) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL491365 | 0.76 | DPP4 (0.35) | SPR | |
| SCHEMBL2186733 | 0.75 | KDM4E (0.48) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL27698607 | 0.74 | KMT2A (0.46) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2186025 | 0.72 | KDM4E (0.46) | KDM4EBRD4ALDH1A1POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| CN-101031567-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2007-09-05 | — | — | CN | disclosed |
| EP-1637529-A1 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof | 4SC AG (DE) | 2006-03-22 | — | — | EP | disclosed |