SCHEMBL4299205

SCHEMBL4299205

O=C(O)c1ccccc1OC(Cl)Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.55
HSD17B10 Q99714 7/20 0.55
HPGD P15428 6/20 0.55
ALDH1A1 P00352 10/20 0.53
HMGB1 P09429 2/20 0.53
NAPRT Q6XQN6 2/20 0.53
ESR1 P03372 1/20 0.53
ITGB3 P05106 1/20 0.53
ITGA2B P08514 1/20 0.53
TSHR P16473 1/20 0.53
GGT1 P19440 1/20 0.53
PTGS1 P23219 1/20 0.53
PTGS2 P35354 1/20 0.53
BLM P54132 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
MAPT P10636 2/20 0.52
USP2 O75604 1/20 0.52
PDE3A Q14432 1/20 0.52
KMT2A Q03164 3/20 0.50
HTT P42858 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20516072 0.86 KDM4E (0.53) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL18700983 0.85 KDM4E (0.56) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL7669351 0.81 KDM4E (0.56) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL28329498 0.80 KDM4E (0.53) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL177388 0.80 KDM4E (0.53) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL104892 0.80 IRAK4 (0.70) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL8528992 0.80 KDM4E (0.55) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL10619157 0.80 KDM4E (0.59) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL975946 0.80 KDM4E (0.55) KDM4EHSD17B10HPGDALDH1A1HMGB1
SCHEMBL8175115 0.80 KDM4E (0.55) KDM4EHSD17B10HPGDALDH1A1HMGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250275540-A1 USE OF PROTOPORPHYRINOGEN OXIDASE BEIJING DABEINONG BIOTECHNOLOGY CO., LTD. (CN) 2025-09-04 US disclosed
EP-4516911-A1 USE OF PROTOPORPHYRINOGEN OXIDASE Beijing Dabeinong Biotechnology Co., Ltd. (CN) 2025-03-05 EP disclosed
US-20250043302-A1 MUTATED HYDROXYPHENYLPYRUVATE DIOXYGENASE POLYPEPTIDE, AND CODING GENE AND USE THEREOF BEIJING DABEINONG BIOTECHNOLOGY CO., LTD. (CN) 2025-02-06 US disclosed
US-20240200091-A1 USE OF PROTOPORPHYRINOGEN OXIDASE BEIJING DABEINONG BIOTECHNOLOGY CO., LTD. (CN) 2024-06-20 US disclosed
US-20240122179-A1 AUXINIC HERBICIDES AND METHODS OF USE THEREOF CORTEVA AGRISCIENCE LLC (US) 2024-04-18 US disclosed
EP-4339290-A1 USE OF PROTOPORPHYRINOGEN OXIDASE Beijing Dabeinong Biotechnology Co., Ltd. (CN) 2024-03-20 EP disclosed
CN-115340987-B Herbicide tolerance protein, coding gene and application thereof 北京大北农生物技术有限公司 2023-12-01 CN disclosed
WO-2023206126-A1 USE OF PROTOPORPHYRINOGEN OXIDASE 北京大北农生物技术有限公司 2023-11-02 WO disclosed
CN-116917486-A Use of protoporphyrinogen oxidase 北京大北农生物技术有限公司 2023-10-20 CN disclosed
US-20230212587-A1 Mutant Hydroxyphenylpyruvate Dioxygenase Polypeptide, Encoding Gene Thereof and Use Therefor BEIJING DABEINONG BIOTECHNOLOGY CO. LTD. (CN) 2023-07-06 US disclosed
US-20060075894-A1 Bioagent air filtration systems UNIVERSITY OF WYOMING RESEARCH CORPORATION D/B/A WESTERN RESEARCH INSTITUTE (US) 2006-04-13 US disclosed
US-20060070952-A1 Charge-based water filtration systems UNIVERSITY OF WYOMING RESEARCH CORPORATION D/B/A (US) 2006-04-06 US disclosed
WO-2005014160-A1 BIOAGENT AIR FILTRATION SYSTEMS THE UNIVERSITY OF WYOMING RESEARCH CORPORATION D/B/A WESTERN RESEARCH INSTITUTE (US) 2005-02-17 WO disclosed
WO-2005012194-A1 CHARGE-BASED WATER FILTRATION SYSTEMS THE UNIVERSITY OF WYOMING RESEARCH CORPORATION D/B/A WESTERN RESEARCH INSTITUTE (US) 2005-02-10 WO disclosed
EP-1024691-A4 SOLUBLE POLYMER BASED MATRIX FOR CHEMICALLY ACTIVE WATER INSOLUBLE COMPONENTS ISP INVESTMENTS INC (US) 2004-08-18 EP disclosed
EP-1265897-A1 NON-AMIDINE CONTAINING PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-18 EP disclosed
WO-2001070743-A1 NON-AMIDINE CONTAINING PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2001-09-27 WO disclosed
EP-1024691-A1 SOLUBLE POLYMER BASED MATRIX FOR CHEMICALLY ACTIVE WATER INSOLUBLE COMPONENTS ISP INVESTMENTS INC. (US) 2000-08-09 EP disclosed
WO-1998033378-A1 SOLUBLE POLYMER BASED MATRIX FOR CHEMICALLY ACTIVE WATER INSOLUBLE COMPONENTS ISP INVESTMENTS INC. (US) 1998-08-06 WO disclosed
WO-1992021656-A1 WATER-SOLUBLE BIOLOGICALLY ACTIVE AMMONIUM SALTS ISP INVESTMENTS INC. (US) 1992-12-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240122179-A1 AUXINIC HERBICIDES AND METHODS OF USE THEREOF DDT, HACL2, ALAD KDM4E 3249/4885HSD17B10 99/4885HPGD 2047/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.