Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8755820 | 1.00 | KDM4E (0.47) | KDM4ETDP1PIK3CDHSD17B10RXRA | |
| SCHEMBL3683020 | 0.99 | KDM4E (0.45) | KDM4ETDP1PIK3CDHSD17B10RXRA | |
| SCHEMBL4300271 | 0.89 | KDM4E (0.39) | KDM4ETDP1PIK3CDHSD17B10HSP90AA1 | |
| SCHEMBL6263855 | 0.85 | KDM4E (0.37) | KDM4ETDP1PIK3CDHSD17B10HSP90AA1 | |
| SCHEMBL5917486 | 0.76 | KDM4E (0.52) | KDM4ETDP1PIK3CDHSD17B10ALDH1A1 | |
| SCHEMBL17142230 | 0.75 | KDM4E (0.43) | KDM4ETDP1PIK3CDHSD17B10PARP15 | |
| SCHEMBL17142190 | 0.75 | KDM4E (0.37) | KDM4ETDP1PIK3CDHSD17B10PARP15 | |
| SCHEMBL3090005 | 0.75 | PIK3CD (0.53) | KDM4ETDP1PIK3CDHSD17B10ALDH1A1 | |
| SCHEMBL3088454 | 0.73 | PIK3CD (0.51) | KDM4ETDP1PIK3CDHSD17B10PARP15 | |
| SCHEMBL17142241 | 0.72 | KDM4E (0.38) | KDM4ETDP1PIK3CDHSD17B10PARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2889309-B1 | MULTIMER OF EXTRACELLULAR DOMAIN OF PD-1 OR PD-L1 | ONO PHARMACEUTICAL CO (JP) | 2017-12-27 | — | — | EP | disclosed |
| US-9783578-B2 | Immunosuppression modulating compounds | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-10-10 | — | — | US | disclosed |
| EP-2889309-A1 | Tetramer of extracellular domain of PD-L1 | ONO PHARMACEUTICAL CO., LTD. (JP) | 2015-07-01 | — | — | EP | disclosed |
| EP-2468765-B1 | Tetramer of extracellular domain of PD-L1 | ONO PHARMACEUTICAL CO (JP) | 2015-04-22 | — | — | EP | disclosed |
| US-20150087581-A1 | Immunosuppression Modulating Compounds | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-03-26 | — | — | US | disclosed |
| EP-2468765-A9 | Tetramer of extracellular domain of PD-L1 | ONO Pharmaceutical Co., Ltd. (JP) | 2014-12-31 | — | — | EP | disclosed |
| US-8907053-B2 | Immunosuppression modulating compounds | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-12-09 | — | — | US | disclosed |
| US-8574872-B2 | Multimer of extracellular domain of cell surface functional molecule | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| EP-1997887-B1 | MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE | ONO PHARMACEUTICAL CO (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-2585099-A2 | IMMUNOSUPPRESSION MODULATING COMPOUNDS | Aurigene Discovery Technologies Limited (IN) | 2013-05-01 | — | — | EP | disclosed |
| US-8216996-B2 | Multimer of extracellular domain of cell surface functional molecule | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| EP-2468765-A1 | Multimer of extracellular domain of cell surface functional molecule | ONO Pharmaceutical Co., Ltd. (JP) | 2012-06-27 | — | — | EP | disclosed |
| US-20110318373-A1 | IMMUNOSUPPRESSION MODULATING COMPOUNDS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2011-12-29 | — | — | US | disclosed |
| WO-2011161699-A2 | IMMUNOSUPPRESSION MODULATING COMPOUNDS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2011-12-29 | — | — | WO | disclosed |
| US-20090305950-A1 | MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| EP-1997887-A1 | MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE | Kyoto University (JP) | 2008-12-03 | — | — | EP | disclosed |
| EP-0249983-B2 | Reagent kit for use in sandwich immunoassay | MEIDENSHA ELECTRIC MFG CO LTD (JP) | 1997-03-19 | — | — | EP | disclosed |
| EP-0249955-B1 | KIT FOR USE IN SANDWICH IMMUNOASSAY | Kabushiki Kaisha Meidensha (JP) | 1993-03-10 | — | — | EP | disclosed |
| EP-0249955-A2 | Kit for use in sandwich immunoassay | Kabushiki Kaisha Meidensha (JP) | 1987-12-23 | — | — | EP | disclosed |
| EP-0249983-A2 | Reagent kit for use in sandwich immunoassay | Kabushiki Kaisha Meidensha (JP) | 1987-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318373-A1 | IMMUNOSUPPRESSION MODULATING COMPOUNDS | CD274, PDCD1, PDCD1LG2 | KDM4E 2955/4885TDP1 2920/4885PIK3CD 596/4885 |
| US-20150087581-A1 | Immunosuppression Modulating Compounds | CD274, PDCD1, PDCD1LG2 | KDM4E 3035/4885TDP1 2891/4885PIK3CD 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.