Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31688776 | 0.81 | PKM (0.55) | MGAMKMT2AMEN1CYP1A2KDM4E | |
| SCHEMBL4302007 | 0.81 | MGAM (0.42) | MGAMSCN9AITGB1ITGAVHCAR2 | |
| SCHEMBL15045025 | 0.78 | MGAM (0.51) | MGAMKMT2AMEN1KDM4ENPC1 | |
| SCHEMBL10080449 | 0.75 | ALDH1A1 (0.52) | MGAMKMT2AMEN1CYP1A2KDM4E | |
| SCHEMBL1643663 | 0.75 | MGAM (0.51) | MGAMSCN9AKMT2AMEN1NR1H4 | |
| SCHEMBL9126436 | 0.75 | GRIN2D (0.61) | KMT2AMEN1NR1H4GRIN2DGRIN2A | |
| SCHEMBL9176689 | 0.75 | HTR2A (0.53) | KMT2AMEN1CYP1A2CYP2C9AKR1C3 | |
| SCHEMBL6937399 | 0.75 | MGAM (0.47) | MGAMKMT2AMEN1CYP1A2KDM4E | |
| SCHEMBL4304834 | 0.73 | NQO1 (0.51) | SCN9AKDM4EALDH1A1 | |
| SCHEMBL4309914 | 0.73 | MGAM (0.46) | MGAMSCN9AKMT2AMEN1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | claimed |