Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10891353 | 0.86 | MAPT (0.59) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL10893359 | 0.86 | MAPT (0.51) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL5981763 | 0.83 | HCAR3 (0.63) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL30169708 | 0.83 | HCAR3 (0.63) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL8107611 | 0.83 | MAPT (0.60) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL6745448 | 0.81 | MAPT (0.59) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL14063303 | 0.81 | HCAR3 (0.65) | MAPTKDM4EALDH1A1MAPK1TDP1 | |
| SCHEMBL8147273 | 0.80 | MAPT (0.65) | MAPTKDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL16616688 | 0.80 | MAPT (0.55) | MAPTKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL27501764 | 0.79 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134754-A1 | BENZOIMIDAZOLE GLYCINAMIDES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | WO | disclosed |