Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AGER | Q15109 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2091236 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1GAARAB9ANPC1 | |
| SCHEMBL11249510 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E | |
| SCHEMBL863826 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E | |
| SCHEMBL30002532 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E | |
| SCHEMBL2091233 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1GAARAB9ANPC1 | |
| SCHEMBL157188 | 0.82 | RAB9A (0.72) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E | |
| SCHEMBL29757931 | 0.82 | RAB9A (0.72) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E | |
| SCHEMBL18550663 | 0.81 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL1140606 | 0.81 | MAPT (0.61) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E | |
| SCHEMBL6185781 | 0.81 | RAB9A (0.53) | SMN1; SMN2ALDH1A1GAARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010180-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2009-01-07 | — | — | EP | claimed |
| WO-2007124423-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-01 | — | — | WO | claimed |
| EP-3924055-A1 | SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020165834-A1 | SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2020-08-20 | — | — | WO | disclosed |
| EP-3068763-A1 | HYDROBROMIDE SALT OFN-(4-CHLORO-2-HYDROXY-3-((3S)-3-PIPERIDINYLSULFONYL)PHENYL-N'-(3-FLUORO-2-METHYLPHENYL)UREA | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015071235-A1 | HYDROBROMIDE SALT OFN-(4-CHLORO-2-HYDROXY-3-((3S)-3-PIPERIDINYLSULFONYL)PHENYL-N'-(3-FLUORO-2-METHYLPHENYL)UREA | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-05-21 | — | — | WO | disclosed |
| EP-2010180-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007124423-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-01 | — | — | WO | disclosed |
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |