Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | TFEB | P19484 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14562456 | 0.94 | NFE2L2 (0.52) | NFE2L2TFEBMAPTLMNANPC1 | |
| SCHEMBL62156 | 0.94 | NFE2L2 (0.52) | NFE2L2TFEBMAPTLMNANPC1 | |
| SCHEMBL31710835 | 0.94 | NFE2L2 (0.52) | NFE2L2TFEBMAPTLMNANPC1 | |
| SCHEMBL3008171 | 0.86 | NFE2L2 (0.44) | NFE2L2TFEBMAPTLMNANPC1 | |
| SCHEMBL887234 | 0.84 | NFE2L2 (0.55) | NFE2L2MAPTLMNANPC1RAB9A | |
| SCHEMBL14645363 | 0.84 | SMN1; SMN2 (0.48) | NFE2L2TFEBMAPTLMNANPC1 | |
| SCHEMBL19579510 | 0.81 | KDM4E (0.57) | NFE2L2TFEBMAPTLMNANPC1 | |
| SCHEMBL19137920 | 0.80 | NFKB1 (0.47) | NFE2L2MAPTLMNANPC1RAB9A | |
| SCHEMBL887236 | 0.80 | MAPT (0.54) | MAPTLMNANPC1RAB9AKDM4E | |
| Amiloxate SCHEMBL128150 | 0.79 | TDP1 (0.59) | MAPTLMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066407-A2 | ALKYL BENZOATE MIXTURES | Cognis IP Management GmbH (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008037380-A2 | ALKYL BENZOATE MIXTURES | COGNIS IP MANAGEMENT GMBH (DE) | 2008-04-03 | — | — | WO | disclosed |