SCHEMBL430758

SCHEMBL430758

CC(=O)c1ccc(C=C2CC(=O)C(c3c(C)cc(C)cc3C)C2=O)nc1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ RARA P10276 1/20 0.33
▸ RARB P10826 1/20 0.33
▸ RARG P13631 1/20 0.33
▸ RXRA P19793 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ FFAR4 Q5NUL3 1/20 0.31
▸ KCNJ1 P48048 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ LCK P06239 1/20 0.31
▸ KIT P10721 1/20 0.31
▸ SRC P12931 1/20 0.31
▸ MAPT P10636 1/20 0.30
▸ RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL430763 0.86 PROKR1 (0.31) KDM4EL3MBTL1MEN1KMT2AMAPT
SCHEMBL428552 0.83 SPR (0.30) —
SCHEMBL427490 0.83 — —
SCHEMBL430429 0.81 KDM4E (0.37) KDM4EL3MBTL1
SCHEMBL428575 0.79 TERT (0.32) —
SCHEMBL430381 0.78 MAPT (0.48) KDM4EMEN1KMT2AMAPTRAB9A
SCHEMBL464644 0.78 MAPT (0.48) KDM4EMEN1KMT2AMAPTRAB9A
SCHEMBL428660 0.78 NPC1 (0.34) KDM4EMEN1KMT2AMAPTRAB9A
SCHEMBL430432 0.76 LMNA (0.35) KDM4EMAPTRAB9A
SCHEMBL430762 0.75 NPC1 (0.32) KDM4EMEN1KMT2AMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2997824-A1 NOVEL HERBICIDES Syngenta Participations AG. (CH) 2016-03-23 — — EP disclosed
EP-2375898-B1 NOVEL HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2015-09-16 — — EP disclosed
US-8889595-B2 Herbicides SYNGENTA PARTICIPATIONS AG (CH) 2014-11-18 — — US disclosed
US-8889595-B2 Herbicides SYNGENTA PARTICIPATIONS AG (CH) 2014-11-18 — — US disclosed
US-20120065064-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-03-15 — — US disclosed
WO-2010069834-A1 NOVEL HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-06-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065064-A1 NOVEL HERBICIDES DDT, CYP1B1, CYP4X1 RARA 2027/4885RARB 1396/4885RARG 1820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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