Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RARA | P10276 | 4/20 | 0.44 |
| ▸ | RARB | P10826 | 4/20 | 0.44 |
| ▸ | RARG | P13631 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040211 | 0.85 | RARB (0.45) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL5475249 | 0.85 | KDM4E (0.53) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL548737 | 0.82 | MEN1 (0.46) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL5834020 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| Phenol SCHEMBL27448237 | 0.81 | HIF1A (0.45) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL3823755 | 0.80 | KDM4E (0.43) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL18155724 | 0.80 | RARB (0.44) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL18040209 | 0.79 | KDM4E (0.49) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL3759976 | 0.78 | MEN1 (0.46) | KDM4ERARARARBRARGALDH1A1 | |
| SCHEMBL15766044 | 0.77 | SELL (0.47) | KDM4ERARARARBRARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734208-B2 | ADJUSTMENT TRANSFORMING GROWTH FACTOR CONCENTRATION; ANTIINFLAMMATORY AGENTS | NEORX CORPORATION | 2004-05-11 | — | — | US | claimed |
| CN-107427431-B | Antioxidant or anti-aging composition comprising 5-adamantan-1-yl-N- (2, 4-dihydroxybenzyl) -2, 4-dimethoxybenzamide | 株式会社爱茉莉太平洋 | 2021-04-13 | — | — | CN | disclosed |
| EP-3278790-B1 | ANTI-OXIDATIVE OR ANTI-AGING COMPOSITION CONTAINING 5-ADAMANTAN-1-YL-N-(2,4-DIHYDROXYBENZYL)-2,4-DIMETHOXYBENZAMIDE | AMOREPACIFIC CORP (KR) | 2021-03-24 | — | — | EP | disclosed |
| US-20180116933-A1 | ANTI-OXIDATIVE OR ANTI-AGING COMPOSITION CONTAINING 5-ADAMANTAN-1-YL-N-(2,4-DIHYDROXYBENZYL)-2,4-DIMETHOXYBENZAMIDE | AMOREPACIFIC CORPORATION (KR) | 2018-05-03 | — | — | US | disclosed |
| EP-3278790-A2 | ANTI-OXIDATIVE OR ANTI-AGING COMPOSITION CONTAINING 5-ADAMANTAN-1-YL-N-(2,4-DIHYDROXYBENZYL)-2,4-DIMETHOXYBENZAMIDE | Amorepacific Corporation (KR) | 2018-02-07 | — | — | EP | disclosed |
| CN-107427431-A | Include the anti-oxidant or anti-staling composition of 5 adamantane 1 base N (2,4 dihydroxy benzyl) 2,4 dimethoxybenzarnides | 株式会社爱茉莉太平洋 | 2017-12-01 | — | — | CN | disclosed |
| US-9433593-B1 | Composition for anti-inflammation containing 5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide | AMOREPACIFIC CORPORATION (KR) | 2016-09-06 | — | — | US | disclosed |
| CN-103702977-B | Benzoic acid amide compound | 株式会社爱茉莉太平洋 | 2016-08-17 | — | — | CN | disclosed |
| CN-103702977-A | Novel benzoic acid amide compound | AMORE PACIFIC CORP | 2014-04-02 | — | — | CN | disclosed |
| US-7511070-B2 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | PONIARD PHARMACEUTICALS, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-7084171-B2 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | NEORX CORPORATION (US) | 2006-08-01 | — | — | US | disclosed |
| US-20060084696-A1 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | PONIARD PHARMACEUTICALS, INC. | 2006-04-20 | — | — | US | disclosed |
| US-20050020667-A1 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | PONIARD PHARMACEUTICALS, INC. | 2005-01-27 | — | — | US | disclosed |
| US-6734208-B2 | ADJUSTMENT TRANSFORMING GROWTH FACTOR CONCENTRATION; ANTIINFLAMMATORY AGENTS | NEORX CORPORATION | 2004-05-11 | — | — | US | disclosed |
| US-20030064970-A1 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | NEORX CORPORATION | 2003-04-03 | — | — | US | disclosed |
| US-6410587-B1 | FIBROSIS; ALZHEIMER'S DISEASE; ANTIARTHRITIC AGENTS | NEORX CORPORATION | 2002-06-25 | — | — | US | disclosed |
| US-6117911-A | ADMINISTRATION OF AT LEAST ONE THERAPEUTIC AGENT THAT ELEVATES THE LEVEL OF TGF-BETA IN SAID MAMMAL. | NEORX CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1998046588-A2 | COMPOUNDS AND THERAPIES FOR THE PREVENTION OF VASCULAR AND NON-VASCULAR PATHOLOGIES | NEORX CORPORATION (US) | 1998-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084696-A1 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | TGFB1, TGFB2, TEK | KDM4E 3256/4885RARA 1385/4885RARB 527/4885 |
| US-20050020667-A1 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | TGFB1, TGFB2, TEK | KDM4E 3256/4885RARA 1385/4885RARB 527/4885 |
| US-20180116933-A1 | ANTI-OXIDATIVE OR ANTI-AGING COMPOSITION CONTAINING 5-ADAMANTAN-1-YL-N-(2,4-DIHYDROXYBENZYL)-2,4-DIMETHOXYBENZAMIDE | MMP14, DNASE1, MMP15 | KDM4E 515/4885RARA 2089/4885RARB 1643/4885 |
| US-20030064970-A1 | Compounds and therapies for the prevention of vascular and non-vascular pathologies | TGFB1, TGFB2, TEK | KDM4E 3256/4885RARA 1385/4885RARB 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.