Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4311662 | 1.00 | DRD2 (0.35) | DRD2DRD1DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL4322021 | 0.86 | CHEK1 (0.37) | KDM4ESMN1; SMN2CHEK1KDRALDH1A1 | |
| SCHEMBL4314405 | 0.86 | CHEK1 (0.37) | KDM4ESMN1; SMN2CHEK1KDRALDH1A1 | |
| SCHEMBL4314415 | 0.86 | CHEK1 (0.37) | KDM4ESMN1; SMN2CHEK1KDRALDH1A1 | |
| SCHEMBL4322028 | 0.86 | CHEK1 (0.37) | KDM4ESMN1; SMN2CHEK1KDRALDH1A1 | |
| SCHEMBL4321978 | 0.85 | MAPT (0.41) | KDM4ESMN1; SMN2CHEK1BCHEACHE | |
| SCHEMBL4321984 | 0.85 | MAPT (0.41) | KDM4ESMN1; SMN2CHEK1BCHEACHE | |
| SCHEMBL27691448 | 0.79 | CHEK1 (0.37) | KDM4ESMN1; SMN2CHEK1KDRALDH1A1 | |
| SCHEMBL4313807 | 0.78 | LMNA (0.39) | KDM4ECHEK1KDRACHELMNA | |
| SCHEMBL4313814 | 0.78 | LMNA (0.39) | KDM4ECHEK1KDRACHELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | DRD2 2203/4885DRD1 2115/4885DRD3 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.