Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313373 | 0.99 | ACHE (0.67) | ACHE | |
| Bromide SCHEMBL3914120 | 0.98 | ACHE (0.68) | ACHE | |
| SCHEMBL22394534 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL2331841 | 0.81 | ACHE (0.98) | ACHE | |
| SCHEMBL4817498 | 0.80 | — | — | |
| SCHEMBL7895132 | 0.80 | ACHE (1.00) | ACHE | |
| Iodide SCHEMBL17313355 | 0.79 | ACHE (0.98) | ACHE | |
| Bromide SCHEMBL2403769 | 0.79 | ACHE (1.00) | ACHE | |
| SCHEMBL4809826 | 0.78 | — | — | |
| SCHEMBL4810586 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA HRVATSKA D.O.O | 2009-05-28 | — | — | US | disclosed |
| EP-1992616-A1 | Process for the preparation of donepezil and intermediate compounds thereof as well as hydrates of donepezil | Pliva Hrvastka D.O.O. (HR) | 2008-11-19 | — | — | EP | disclosed |
| EP-1910291-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | Pliva-Istrazivanje I Razvoj D.D.O. (HR) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015052-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA ISTRAZIVANJE I RAZVOJ D.O.O. (HR) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | ACHE, BCHE, WIZ | ACHE 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.