Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586966 | 0.86 | TAAR1 (0.56) | ALOX15ALOX5CALM1TAAR1IGF1R | |
| Trifluoroacetic Acid SCHEMBL4313499 | 0.85 | KDM4E (0.47) | ALOX15KDM4ETDP1LDHAALOX5 | |
| SCHEMBL1587009 | 0.82 | TAAR1 (0.55) | ALOX15TDP1ALOX5CALM1TAAR1 | |
| SCHEMBL4313502 | 0.80 | POLB (0.44) | — | |
| Trifluoroacetic Acid SCHEMBL6317983 | 0.77 | LDHA (0.54) | LDHATAAR1 | |
| Trifluoroacetic Acid SCHEMBL6220574 | 0.77 | LDHA (0.54) | LDHATAAR1 | |
| SCHEMBL20394552 | 0.77 | TAAR1 (0.60) | CALM1TAAR1 | |
| Trifluoroacetic Acid SCHEMBL4277214 | 0.77 | ALOX5 (0.47) | ALOX5CALM1FFAR1TAAR1 | |
| SCHEMBL28463183 | 0.76 | KIF11 (0.55) | LDHAALOX5CALM1 | |
| SCHEMBL2926805 | 0.76 | KIF11 (0.55) | LDHAALOX5CALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| EP-2285785-B1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |