SCHEMBL43137

SCHEMBL43137

[c]1ccccc1C1CCCC1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.32
PTPRC P08575 1/20 0.32
PTPRF P10586 1/20 0.32
CDC25B P30305 1/20 0.32
CYP11B2 P19099 1/20 0.31
SLC18A3 Q16572 1/20 0.31
POLB P06746 1/20 0.30
CASP3 P42574 1/20 0.30
SENP7 Q9BQF6 1/20 0.30
SENP6 Q9GZR1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7838054 0.98 CYP11B2 (0.34) PTPN1PTPRCPTPRFCDC25BCYP11B2
SCHEMBL25216 0.98 CYP11B2 (0.34) PTPN1PTPRCPTPRFCDC25BCYP11B2
SCHEMBL677783 0.98 CYP11B2 (0.34) PTPN1PTPRCPTPRFCDC25BCYP11B2
SCHEMBL2911923 0.98 CYP11B2 (0.34) PTPN1PTPRCPTPRFCDC25BCYP11B2
SCHEMBL42932 0.95
SCHEMBL24524 0.91
SCHEMBL694970 0.83 SLC18A3 (0.44) SLC18A3
SCHEMBL17090722 0.83
SCHEMBL2761445 0.83
SCHEMBL2814490 0.82 TSHR (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 551 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11807620-B2 Quinazolinone compounds and related compounds Plexium, Inc. (US) 2023-11-07 US claimed
US-11731954-B2 Histone demethylase inhibitors CELGENE QUANTICEL RES INC (US) 2023-08-22 US claimed
CN-115707712-A Peptide amide compound, pharmaceutically acceptable salt and stereoisomer thereof, and application thereof 天地恒一制药股份有限公司 2023-02-21 CN claimed
CN-115466290-A Narrow-spectrum green phosphorescent platinum complex, preparation method and application thereof, and organic light-emitting diode device 中国石油化工股份有限公司 2022-12-13 CN claimed
EP-3897644-A1 COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF Revolution Medicines, Inc. (US) 2021-10-27 EP claimed
CN-113498342-A Compounds involved in synergistic binding and uses thereof 锐新医药公司 2021-10-12 CN claimed
US-20210238161-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2021-08-05 US claimed
US-11001568-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2021-05-11 US claimed
CN-108276401-B Inhibitors of influenza virus replication and uses thereof 广东东阳光药业有限公司 2020-12-22 CN claimed
EP-3383853-B1 HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR (LXR) BETA AGONISTS FOR TREATING E.G. ALZHEIMER'S DISEASE MERCK SHARP & DOHME (US) 2020-11-04 EP claimed
EP-0069385-B1 USE OF EUCALYPTOL FOR ENHANCING SKIN PERMEATION OF BIOAFFECTING AGENTS MERCK & CO. INC. (US) 1987-10-14 EP claimed
CN-86102227-A The preparation method of 1-alkylamino-2-propyl alcohol that arylolycidyl ethers and 3-replace 1987-02-04 CN claimed
EP-0102520-B1 PROCESS FOR THE INVERSION OF THE CONFIGURATION OF OPTICALLY ACTIVE COMPOUNDS, AND OPTICALLY ACTIVE INTERMEDIATES FOR THIS PROCESS HOECHST AKTIENGESELLSCHAFT (DE) 1986-10-29 EP claimed
EP-0193227-A1 Process for the preparation of arylglycidyl ethers and 3-substituted 1-alkylamino-2-propanols GIST-BROCADES N.V. (NL) 1986-09-03 EP claimed
US-4363808-A N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines BERLEX LABORATORIES, INC. (US) 1982-12-14 US claimed
EP-0034116-A2 N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines BERLEX LABORATORIES, INC. (US) 1981-08-19 EP claimed
US-4182911-A BETA-ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-01-08 US claimed
US-3971804-A ACARICIDES, FUNGICIDES, INSECTICIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US claimed
US-3941829-A PESTICIDE CIBA-GEIGY CORPORATION (US) 1976-03-02 US claimed
US-3935250-A PESTICIDE CIBA-GEIGY CORPORATION (US) 1976-01-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001568-B2 Histone demethylase inhibitors KDM1B, KDM1A, BMI1 PTPN1 654/4885PTPRC 1265/4885PTPRF 1507/4885
US-11731954-B2 Histone demethylase inhibitors KDM1B, KDM1A, BMI1 PTPN1 654/4885PTPRC 1265/4885PTPRF 1507/4885
US-11807620-B2 Quinazolinone compounds and related compounds NQO2, COQ8A, PARK7 PTPN1 2500/4885PTPRC 1365/4885PTPRF 1629/4885
US-20210238161-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, BMI1 PTPN1 654/4885PTPRC 1265/4885PTPRF 1507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.