Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4308265 | 0.79 | — | — | |
| SCHEMBL4312759 | 0.74 | FDPS (0.37) | HTR6 | |
| SCHEMBL8861716 | 0.73 | HTR2A (0.44) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL27617903 | 0.73 | FDPS (0.36) | HTR6 | |
| SCHEMBL8831405 | 0.71 | HTR2A (0.34) | SIGMAR1HTR6HTR2A | |
| SCHEMBL8831509 | 0.71 | RET (0.41) | SIGMAR1HTR6HTR2A | |
| SCHEMBL1452608 | 0.70 | HTR6 (0.41) | SIGMAR1HTR6HTR2A | |
| SCHEMBL1030004 | 0.70 | HTR2A (0.38) | SIGMAR1HTR6HTR2A | |
| SCHEMBL9144761 | 0.69 | HTR2A (0.36) | SIGMAR1HTR6HTR2A | |
| Lithium SCHEMBL5702700 | 0.69 | HTR6 (0.40) | SIGMAR1HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541481-B2 | Monocyclopentadienyl complex | BASELL POLYOLEFIN GMBH (DE) | 2009-06-02 | — | — | US | disclosed |
| US-20070155918-A1 | Monocyclopentadienyl complex | BASELL POLYOLEFINE GMBH (DE) | 2007-07-05 | — | — | US | disclosed |
| US-20060089253-A1 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2006-04-27 | — | — | US | disclosed |
| EP-1534724-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2006-03-08 | — | — | EP | disclosed |
| EP-1534724-A2 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004020479-A2 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155918-A1 | Monocyclopentadienyl complex | COASY, PCBP1, ORC3 | SIGMAR1 4103/4885HTR6 3910/4885HTR2A 4238/4885 |
| US-20060089253-A1 | Monocyclopentadienyl complexes | COASY, PCBP1, ORC3 | SIGMAR1 3552/4885HTR6 3147/4885HTR2A 3991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.