Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158819 | 0.79 | L3MBTL1 (0.64) | MAPTL3MBTL1EGFRERBB2RAB9A | |
| SCHEMBL6902503 | 0.79 | MAPT (0.42) | MAPTL3MBTL1EGFRERBB2RAB9A | |
| SCHEMBL15104669 | 0.74 | RAB9A (0.46) | MAPTL3MBTL1EGFRERBB2RAB9A | |
| SCHEMBL2772081 | 0.73 | RAB9A (0.50) | MAPTL3MBTL1EGFRERBB2RAB9A | |
| SCHEMBL374899 | 0.73 | KMT2A (0.46) | L3MBTL1EGFRERBB2RAB9ANPC1 | |
| SCHEMBL22908698 | 0.72 | ALDH1A1 (0.53) | MAPTL3MBTL1EGFRERBB2RAB9A | |
| SCHEMBL27742417 | 0.72 | GAA (0.45) | MAPTL3MBTL1EGFRERBB2RAB9A | |
| SCHEMBL623831 | 0.72 | METAP1 (0.46) | RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL29476654 | 0.72 | METAP1 (0.46) | RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL28680870 | 0.71 | HPGD (0.49) | RAB9ANPC1HPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155551-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2009-12-23 | — | — | WO | disclosed |