Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13319641 | 0.87 | ALDH1A1 (0.50) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL431969 | 0.86 | MEN1 (0.36) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL9252191 | 0.83 | TSHR (0.41) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL434384 | 0.83 | TSHR (0.34) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL1179382 | 0.82 | TSHR (0.43) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL1146478 | 0.80 | ALDH1A1 (0.36) | TSHRMEN1KMT2ATHRBALDH1A1 | |
| SCHEMBL1639686 | 0.79 | CYP3A4 (0.32) | TSHR | |
| SCHEMBL11289726 | 0.78 | MEN1 (0.43) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL5705793 | 0.78 | SMN1; SMN2 (0.39) | TSHRMEN1KMT2ATHRBALDH1A1 | |
| SCHEMBL27167532 | 0.77 | ALDH1A1 (0.48) | TSHRMEN1KMT2ATHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546235-B1 | WATER-SOLUBLE POLYMER ALKANALS | NEKTAR THERAPEUTICS (US) | 2021-10-20 | — | — | EP | disclosed |
| US-8853325-B2 | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853325-B2 | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120065429-A1 | WATER-SOLUBLE POLYMER ALKANALS | NEKTAR THERAPEUTICS (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065429-A1 | WATER-SOLUBLE POLYMER ALKANALS | NEKTAR THERAPEUTICS (US) | 2012-03-15 | — | — | US | disclosed |
| US-8076412-B2 | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS (US) | 2011-12-13 | — | — | US | disclosed |
| US-8076412-B2 | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS (US) | 2011-12-13 | — | — | US | disclosed |
| US-20110034737-A1 | Water-Soluble Polymer Alkanals | NEKTAR THERAPEUTICS (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034737-A1 | Water-Soluble Polymer Alkanals | NEKTAR THERAPEUTICS (US) | 2011-02-10 | — | — | US | disclosed |
| US-7838595-B2 | high purity; storage stability; electrophilically activated polymer derivatives with aldehyde functionality for conjugating to biologically active molecules; drug-polymer conjugate; | NEKTAR THERAPEUTICS (US) | 2010-11-23 | — | — | US | disclosed |
| CN-1329427-C | Water soluble polymer alkanals | NEKTAR THERAPEUTICS CORP (US) | 2007-08-01 | — | — | CN | disclosed |
| US-7157546-B2 | Polyoxyethylene glycol; purity, storage stability | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157546-B2 | Polyoxyethylene glycol; purity, storage stability | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-01-02 | — | — | US | disclosed |
| US-20060194940-A1 | 2-methylbutyraldehyde diethyl acetal end capped polyoxyethylene glycol; polyalkylene oxide, polyivnylpyrrolidone, polyvinyl alcohol, polyoxazoline etc. endcapped with polyetherpolyamine copolymers or oligomers covalently attached to diacetal tetramethylene group | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2006-08-31 | — | — | US | disclosed |
| CN-1763122-A | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS AL CORP (US) | 2006-04-26 | — | — | CN | disclosed |
| EP-1591467-A1 | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone | Nektar Therapeutics Al, Corporation (US) | 2005-11-02 | — | — | EP | disclosed |
| CN-1688631-A | Water soluble polymer alkanals | NEKTAR THERAPEUTICS AL CORP (US) | 2005-10-26 | — | — | CN | disclosed |
| EP-1546235-A2 | WATER-SOLUBLE POLYMER ALKANALS | Nektar Therapeutics Al, Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040116649-A1 | Polyoxyethylene glycol; purity, storage stability | NEKTAR THERAPEUTICS | 2004-06-17 | — | — | US | disclosed |
| WO-2004022630-A2 | WATER-SOLUBLE POLYMER ALKANALS | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065429-A1 | WATER-SOLUBLE POLYMER ALKANALS | ALK, ALKBH3, AQP1 | TSHR 4866/4885MEN1 4247/4885KMT2A 1185/4885 |
| US-20110034737-A1 | Water-Soluble Polymer Alkanals | ALK, ALKBH3, AQP1 | TSHR 4866/4885MEN1 4247/4885KMT2A 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.