Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319487 | 0.78 | TRPV1 (0.53) | TRPV1HSD11B1GAA | |
| SCHEMBL4319481 | 0.78 | TRPV1 (0.53) | TRPV1HSD11B1GAA | |
| SCHEMBL4319129 | 0.77 | TRPV1 (0.52) | TRPV1HSD11B1HCRTR1HCRTR2GAA | |
| SCHEMBL4776367 | 0.73 | TRPV1 (0.43) | TRPV1HSD11B1HCRTR1HCRTR2GAA | |
| SCHEMBL13783793 | 0.72 | TRPV1 (0.52) | TRPV1HSD11B1HCRTR1HCRTR2GAA | |
| SCHEMBL4320157 | 0.68 | EPHX2 (0.56) | TRPV1HSD11B1GAANPC1RAB9A | |
| SCHEMBL4482959 | 0.65 | EPHX2 (0.59) | TRPV1HSD11B1GAANPC1RAB9A | |
| SCHEMBL14973800 | 0.65 | EPHX2 (0.59) | TRPV1HSD11B1HCRTR1HCRTR2GAA | |
| SCHEMBL4274909 | 0.63 | TRPV1 (0.80) | TRPV1GAACA12CA1CA2 | |
| SCHEMBL1336559 | 0.62 | RBP4 (0.43) | TRPV1HSD11B1HCRTR1HCRTR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009090548-A2 | 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-23 | — | — | WO | disclosed |