Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | RECQL | P46063 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457398 | 1.00 | GPR35 (0.55) | GPR35ALOX15ALOX12GRM8GRM4 | |
| SCHEMBL5595045 | 0.87 | GPR35 (0.56) | GPR35ALOX15ALOX12GRM8GRM4 | |
| SCHEMBL11032472 | 0.85 | GPR35 (0.58) | GPR35ALOX15ALOX12GRM8GRM4 | |
| SCHEMBL2883857 | 0.82 | TSHR (0.53) | GPR35ALOX15ALOX12EPAS1APP | |
| SCHEMBL26352809 | 0.82 | TSHR (0.53) | GPR35ALOX15ALOX12EPAS1APP | |
| SCHEMBL26352787 | 0.82 | TSHR (0.53) | GPR35ALOX15ALOX12EPAS1APP | |
| SCHEMBL15887339 | 0.81 | GPR35 (0.50) | GPR35ALOX15ALOX12GRM8GRM4 | |
| SCHEMBL13898660 | 0.81 | HPGD (0.50) | GPR35ALOX15ALOX12GRM8GRM4 | |
| SCHEMBL4142382 | 0.81 | GRM8 (0.50) | GPR35GRM8GRM4SIRT6CYP1A2 | |
| SCHEMBL24347083 | 0.81 | TSHR (0.55) | EPAS1APPMAPTTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1793823-B1 | PHOSPHATE CONTAINING PRODRUGS OF SULFONYL HYDRAZINES AS HYPOXIA-SELECTIVE ANTINEOPLASTIC AGENTS | VION PHARMACEUTICALS INC (US) | 2012-08-08 | — | — | EP | disclosed |
| US-20090075945-A1 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents | VION PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | US | disclosed |
| US-7405317-B2 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents | VION PHARMACEUTICALS INC. (US) | 2008-07-29 | — | — | US | disclosed |
| EP-1793823-A2 | SULFONYL HYDRAZINES AS HYPOXIA-SELECTIVE ANTINEOPLASTIC AGENTS | Vion Pharmaceuticals, Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| US-20060089332-A1 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents | NANOSHIFT, LLC | 2006-04-27 | — | — | US | disclosed |
| WO-2006034266-A2 | SULFONYL HYDRAZINES AS HYPOXIA-SELECTIVE ANTINEOPLASTIC AGENTS | VION PHARMACEUTICALS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089332-A1 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents | HIF1AN, HIF1A, EGLN3 | GPR35 861/4885ALOX15 1805/4885ALOX12 2177/4885 |
| US-20090075945-A1 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents | HIF1AN, HIF1A, SLC20A1 | GPR35 979/4885ALOX15 2960/4885ALOX12 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.