Sugi Predict

Sugi Predict / Compounds / SCHEMBL5595045

SCHEMBL5595045

SCHEMBL5595045

CC(C)c1ccc([N+](=O)[O-])c(O)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR35 Q9HC97 2/20 0.56
▸ TRPA1 O75762 1/20 0.50
▸ PTGS1 P23219 1/20 0.50
▸ CACNA1C Q13936 1/20 0.50
▸ TYR P14679 2/20 0.49
▸ SIRT6 Q8N6T7 1/20 0.46
▸ RNASEH1 O60930 1/20 0.46
▸ GRM8 O00222 1/20 0.45
▸ GRM4 Q14833 1/20 0.45
▸ ALOX12 P18054 3/20 0.45
▸ ALOX15 P16050 3/20 0.45
▸ ALDH1A1 P00352 5/20 0.44
▸ HTT P42858 2/20 0.44
▸ HIF1A Q16665 2/20 0.44
▸ GAA P10253 2/20 0.44
▸ MAPT P10636 5/20 0.44
▸ HPGD P15428 4/20 0.44
▸ CYP3A4 P08684 3/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ HSD17B10 Q99714 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7940108 0.89 GPR35 (0.46) GPR35TRPA1PTGS1CACNA1CTYR
SCHEMBL4457398 0.87 GPR35 (0.55) GPR35SIRT6GRM8GRM4ALOX12
SCHEMBL4319781 0.87 GPR35 (0.55) GPR35SIRT6GRM8GRM4ALOX12
SCHEMBL1026668 0.85 ALDH1A1 (0.56) GPR35TRPA1PTGS1CACNA1CTYR
SCHEMBL11032472 0.83 GPR35 (0.58) GPR35SIRT6GRM8GRM4ALOX12
SCHEMBL15887339 0.83 GPR35 (0.50) GPR35SIRT6GRM8GRM4ALOX12
SCHEMBL4142382 0.83 GRM8 (0.50) GPR35PTGS1SIRT6GRM8GRM4
SCHEMBL13898660 0.83 HPGD (0.50) GPR35SIRT6GRM8GRM4ALOX12
SCHEMBL4547845 0.82 TSHR (0.55) GPR35ALDH1A1HTTHIF1AMAPT
SCHEMBL8185669 0.81 GPR35 (0.51) GPR35SIRT6GRM8GRM4ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260022122-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME CHECKMATE THERAPEUTICS INC. (KR) 2026-01-22 — — US disclosed
US-20240409533-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-12-12 — — US disclosed
CN-113874074-B HMOX1 inducers 米托布里奇公司 2024-11-01 — — CN disclosed
US-12071433-B2 HMOX1 inducers Astellas Engineered Small Molecules US, Incorporated (US) 2024-08-27 — — US disclosed
US-20240051952-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-02-15 — — US disclosed
WO-2023229346-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME 주식회사 체크메이트테라퓨틱스 2023-11-30 — — WO disclosed
US-20230142739-A1 PROTEIN-PROTEIN INTERACTION STABILIZERS UNIV CALIFORNIA (US) 2023-05-11 — — US disclosed
US-20220177460-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2022-06-09 — — US disclosed
EP-3952990-A1 HMOX1 INDUCERS Mitobridge, Inc. (US) 2022-02-16 — — EP disclosed
CN-113874074-A HMOX1 inducers 米托布里奇公司 2021-12-31 — — CN disclosed
US-6005008-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1999-12-21 — — US disclosed
CN-1215990-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORP (US) 1999-05-05 — — CN disclosed
US-5886044-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1999-03-23 — — US disclosed
EP-0896531-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-02-17 — — EP disclosed
US-5780483-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1998-07-14 — — US disclosed
EP-0809492-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-12-03 — — EP disclosed
WO-1997029743-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-08-21 — — WO disclosed
WO-1996025157-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-08-22 — — WO disclosed
US-5334225-A Imparts color tone of high chroma; excellent in coloring power and fastness KAO CORPORATION (JP) 1994-08-02 — — US disclosed
EP-0579204-A2 Dye composition for a keratinous fiber KAO CORPORATION (JP) 1994-01-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240409533-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS GPR35 4365/4885TRPA1 2084/4885PTGS1 9/4885
US-12071433-B2 HMOX1 inducers HMOX1, HMOX2, HMBS GPR35 4068/4885TRPA1 2016/4885PTGS1 8/4885
US-20240051952-A1 HMOX1 INDUCERS HMOX1, HMOX2, QSOX1 GPR35 3984/4885TRPA1 2658/4885PTGS1 20/4885
US-20220177460-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS GPR35 4068/4885TRPA1 2016/4885PTGS1 8/4885
US-20230142739-A1 PROTEIN-PROTEIN INTERACTION STABILIZERS HSPBP1, HSPA8, HSPH1 GPR35 4020/4885TRPA1 4635/4885PTGS1 3963/4885
US-20260022122-A1 NOVEL COMPOUND FOR INHIBITING NAMPT, AND COMPOSITION INCLUDING SAME NAMPT, NAPRT, NNT GPR35 2281/4885TRPA1 1816/4885PTGS1 2492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.