Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320035 | 0.91 | LMNA (0.44) | LMNATBXAS1HPGDMCHR1NPC1 | |
| SCHEMBL4335986 | 0.85 | NPC1 (0.47) | LMNATBXAS1HPGDPOLBNPC1 | |
| SCHEMBL13577942 | 0.84 | LMNA (0.43) | LMNATBXAS1HPGDPOLBNPC1 | |
| SCHEMBL4337924 | 0.83 | DRD2 (0.43) | LMNANPC1RAB9ASMN1; SMN2HTR2A | |
| SCHEMBL13577998 | 0.83 | LMNA (0.47) | LMNATBXAS1HPGDPOLBNPC1 | |
| SCHEMBL4333764 | 0.82 | LMNA (0.42) | LMNATBXAS1HPGDPOLBNPC1 | |
| SCHEMBL13578023 | 0.82 | TLR8 (0.42) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13577944 | 0.78 | LMNA (0.45) | LMNATBXAS1HPGDPOLBNPC1 | |
| SCHEMBL13577939 | 0.78 | NPSR1 (0.42) | LMNAHPGDPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4330823 | 0.78 | RAB9A (0.43) | LMNATBXAS1HPGDMCHR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |