Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330789 | 0.92 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2LMNADRD2 | |
| SCHEMBL13577942 | 0.90 | LMNA (0.43) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL4337924 | 0.89 | DRD2 (0.43) | NPC1RAB9ASMN1; SMN2LMNADRD2 | |
| SCHEMBL4333764 | 0.88 | LMNA (0.42) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL4340863 | 0.85 | PTAFR (0.42) | NPC1RAB9ASMN1; SMN2LMNADRD2 | |
| SCHEMBL4319941 | 0.85 | LMNA (0.42) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL13577998 | 0.85 | LMNA (0.47) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL13577956 | 0.84 | LMNA (0.47) | RAB9ASMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL4331873 | 0.83 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2DRD2DRD3 | |
| SCHEMBL4328379 | 0.82 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |