Myricanone

Myricanone

SCHEMBL432252

COc1c2cc(c(O)c1OC)CCCCC(=O)CCc1ccc(O)c-2c1

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 2/20 0.60
NFKB2 Q00653 1/20 0.60
RELA Q04206 1/20 0.60
CETP P11597 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP2C19 P33261 1/20 0.34
MAOB P27338 1/20 0.33
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33
TUBB4B P68371 1/20 0.33
TUBB3 Q13509 1/20 0.33
TUBB2A Q13885 1/20 0.33
TUBB8 Q3ZCM7 1/20 0.33
TUBA3E Q6PEY2 1/20 0.33
TUBA1A Q71U36 1/20 0.33
TUBA1C Q9BQE3 1/20 0.33
TUBB6 Q9BUF5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Myricanone SCHEMBL29904784 1.00 NFKB1 (0.60) NFKB1NFKB2RELACETPCYP1A2
SCHEMBL18649496 0.89 NFKB1 (0.46) NFKB1NFKB2RELACETPMAOB
SCHEMBL21693012 0.85 NFKB1 (0.53) NFKB1NFKB2RELACETPMAOB
SCHEMBL21693008 0.83 NFKB1 (0.48) NFKB1NFKB2RELACETPKDM4E
SCHEMBL16488707 0.81 NFKB1 (0.40) NFKB1NFKB2RELACETP
SCHEMBL16488711 0.81 NFKB1 (0.40) NFKB1NFKB2RELACETP
SCHEMBL15113092 0.81 NFKB1 (0.43) NFKB1NFKB2RELACETPCYP1A2
SCHEMBL21693006 0.81 NFKB1 (0.43) NFKB1NFKB2RELACETPCYP1A2
SCHEMBL433314 0.81 NFKB1 (0.43) NFKB1NFKB2RELACETPCYP1A2
SCHEMBL21692990 0.80 NFKB1 (0.40) NFKB1NFKB2RELACETPCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
US-9206103-B2 Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases UNIVERSITY OF SOUTH FLORIDA (US) 2015-12-08 US claimed
US-20150072029-A1 MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES UNIV SOUTH FLORIDA (US) 2015-03-12 US claimed
US-20130184353-A1 MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES UNIVERSITY OF SOUTH FLORIDA (US) 2013-07-18 US claimed
WO-2012012798-A2 MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES UNIVERSITY OF SOUTH FLORIDA (US) 2012-01-26 WO claimed
EP-1569628-B1 NOVEL USE OF LYCOPENE FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ANDROGEN SIGNALLING DSM IP ASSETS BV (NL) 2009-07-22 EP claimed
US-20060069151-A1 Novel use of lycopene DSM IP ASSETS B.V. (NL) 2006-03-30 US claimed
EP-1569628-A1 NOVEL USE OF LYCOPENE DSM IP Assets B.V. (NL) 2005-09-07 EP claimed
WO-2004052351-A1 NOVEL USE OF LYCOPENE DSM IP ASSETS B.V. (CH) 2004-06-24 WO claimed
US-12568985-B2 Milkfat or butterfat formulations Savor Foods Limited (US) 2026-03-10 US disclosed
EP-4658082-A2 MILKFAT OR BUTTERFAT FORMULATIONS Savor Foods Limited (US) 2025-12-10 EP disclosed
US-20250161394-A1 Compositions Comprising Kavalactones NATURAL EXTRACTION SYS LLC (US) 2025-05-22 US disclosed
CN-118987216-A Use of endoplasmic reticulum stress inhibitor in preparation of medicine for eliminating or relieving liver toxicity caused by pezopanib 杭州颐柏健康管理有限公司 2024-11-22 CN disclosed
EP-3756660-B1 MEDICAMENT HAVING ANTI-INFLAMMATORY BOWEL DISEASE FUNCTION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SUZHOU PHARMAVAN CO LTD (CN) 2024-11-13 EP disclosed
EP-1494993-A2 NOVEL CURCUMIN ANALOGUES AND USES THEREOF UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-01-12 EP disclosed
US-6790979-B2 USE AS ANTITUMOR AGENTS, PARTICULARLY FOR THE TREATMENT OF CANCERS SUCH AS COLON, SKIN AND PROSTATE CANCER AND TO INDUCE ANDROGEN RECEPTOR ANTAGONIST ACTIVITY IN SUBJECT WITH ANDROGEN-RELATED AFFLICTION UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2004-09-14 US disclosed
WO-2004052351-A1 NOVEL USE OF LYCOPENE DSM IP ASSETS B.V. (CH) 2004-06-24 WO disclosed
WO-2003088927-A2 NOVEL CURCUMIN ANALOGUES AND USES THEREOF UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2003-10-30 WO disclosed
US-20030203933-A1 Novel curcumin analogues and uses thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130184353-A1 MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES MAPT, APP, BACE1 NFKB1 2934/4885NFKB2 2989/4885RELA 2588/4885
US-20150072029-A1 MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES MAPT, APP, BACE1 NFKB1 2934/4885NFKB2 2989/4885RELA 2588/4885
US-20030203933-A1 Novel curcumin analogues and uses thereof AR, NR5A1, BRDT NFKB1 1410/4885NFKB2 1001/4885RELA 1044/4885
US-12568985-B2 Milkfat or butterfat formulations FABP4, DGAT2, LIPC NFKB1 4371/4885NFKB2 3547/4885RELA 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.