Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17823329 | 0.88 | LMNA (0.49) | LMNAALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL30686627 | 0.83 | ALDH1A1 (0.58) | LMNAALDH1A1TDP1SIRT6HTT | |
| SCHEMBL4142866 | 0.83 | ALDH1A1 (0.58) | LMNAALDH1A1TDP1SIRT6HTT | |
| SCHEMBL10817393 | 0.82 | ALDH1A1 (0.56) | LMNAALDH1A1TDP1SIRT6HTT | |
| SCHEMBL6826580 | 0.81 | MAPT (0.52) | LMNAALDH1A1HTTL3MBTL1ALDH3A1 | |
| SCHEMBL26087358 | 0.80 | KMT2A (0.51) | LMNAALDH1A1TDP1SIRT6L3MBTL1 | |
| SCHEMBL30977610 | 0.79 | ATM (0.55) | LMNAALDH1A1TDP1HTTALDH3A1 | |
| SCHEMBL11065023 | 0.79 | MEN1 (0.46) | LMNAALDH1A1HTTALDH3A1RAB9A | |
| SCHEMBL10477079 | 0.79 | ALDH1A1 (0.53) | LMNAALDH1A1TDP1SIRT6HTT | |
| SCHEMBL692339 | 0.79 | ATM (0.55) | LMNAALDH1A1TDP1HTTALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144632-A1 | NOVEL COMPOUNDS | PFIZER LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |