SCHEMBL432405

SCHEMBL432405

COc1cc(C=CCOC(=O)C=Cc2ccc(O)cc2)ccc1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MET P08581 8/20 0.69
CA12 O43570 4/20 0.69
CA4 P22748 4/20 0.69
CA6 P23280 4/20 0.69
CA5A P35218 4/20 0.69
CA7 P43166 4/20 0.69
CA9 Q16790 4/20 0.69
CA14 Q9ULX7 4/20 0.69
CA5B Q9Y2D0 4/20 0.69
HTR7 P34969 1/20 0.69
MAOB P27338 3/20 0.69
ABCB1 P08183 2/20 0.69
AKR1B1 P15121 2/20 0.69
MAOA P21397 2/20 0.69
EPHX2 P34913 1/20 0.64
CYP2D6 P10635 3/20 0.60
CYP2C9 P11712 2/20 0.60
TSHR P16473 2/20 0.60
HSD17B10 Q99714 2/20 0.60
SNCA P37840 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20515823 1.00 MET (0.69) METCA12CA4CA6CA5A
SCHEMBL20515821 1.00 MET (0.69) METCA12CA4CA6CA5A
SCHEMBL20515824 1.00 MET (0.69) METCA12CA4CA6CA5A
SCHEMBL13499768 1.00 MET (0.69) METCA12CA4CA6CA5A
SCHEMBL29579409 1.00 MET (0.69) METCA12CA4CA6CA5A
SCHEMBL434930 0.95 MAOB (0.76) METCA12CA4CA6CA5A
SCHEMBL27520787 0.95 MAOB (0.76) METCA12CA4CA6CA5A
SCHEMBL10054940 0.95 MAOB (0.76) METCA12CA4CA6CA5A
SCHEMBL22203998 0.92 CA12 (0.71) METCA12CA4CA6CA5A
SCHEMBL19553741 0.92 CA12 (0.71) METCA12CA4CA6CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11981904-B2 BAHD acyltransferases WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2024-05-14 US disclosed
US-11807875-B2 Feruloyl-CoA:monolignol transferases WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2023-11-07 US disclosed
US-11807876-B2 P-coumaroyl-CoA:monolignol transferases WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2023-11-07 US disclosed
US-11326178-B2 P-coumaroyl-CoA:monolignol transferase WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2022-05-10 US disclosed
US-20220002744-A1 BAHD ACYLTRANSFERASES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2022-01-06 US disclosed
US-20210207104-A1 FERULOYL-COA:MONOLIGNOL TRANSFERASES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-07-08 US disclosed
US-20210095263-A1 P-COUMAROYL-COA:MONOLIGNOL TRANSFERASES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-04-01 US disclosed
US-10883089-B2 Feruloyl-CoA:monolignol transferases WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-01-05 US disclosed
US-10883090-B2 P-coumaroyl-CoA:monolignol transferases WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-01-05 US disclosed
US-10428342-B2 P-coumaroyl-CoA:monolignol transferase BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2019-10-01 US disclosed
EP-2596104-B1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE UNIV MICHIGAN STATE (US) 2016-11-09 EP disclosed
US-9487794-B2 Feruloyl-CoA:monolignol transferase BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2016-11-08 US disclosed
US-9441235-B2 Feruloyl-CoA:monolignol transferase WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2016-09-13 US disclosed
US-20160046955-A1 p-Coumaroyl-CoA:Monolignol Transferase BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2016-02-18 US disclosed
US-20130219547-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2013-08-22 US disclosed
US-20130203973-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE ENERGY, UNITED STATES DEPARTMENT OF 2013-08-08 US disclosed
EP-2596103-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE Board Of Trustees Of Michigan State University (US) 2013-05-29 EP disclosed
EP-2596104-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE Board Of Trustees Of Michigan State University (US) 2013-05-29 EP disclosed
WO-2012012741-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2012-01-26 WO disclosed
WO-2012012698-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2012-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203973-A1 FERULOYL-CoA:MONOLIGNOL TRANSFERASE COASY, FDFT1, FER MET 1999/4885CA12 3269/4885CA4 938/4885
US-11981904-B2 BAHD acyltransferases NAT10, ACOT7, ACAT2 MET 4179/4885CA12 3928/4885CA4 3571/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.