Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936433 | 1.00 | KDM4E (0.58) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL13936432 | 1.00 | KDM4E (0.58) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL13752055 | 0.85 | KDM4E (0.50) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL17560257 | 0.85 | KDM4E (0.46) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL14155671 | 0.84 | KDM4E (0.44) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL12107463 | 0.81 | KDM4E (0.46) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL4762422 | 0.81 | KDM4E (0.65) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL14156359 | 0.81 | CYP2C19 (0.41) | KDM4EMAPK1HIF1APAOXSIRT6 | |
| SCHEMBL10408284 | 0.79 | KDM4E (0.52) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL15981282 | 0.79 | KDM4E (0.70) | KDM4EMAPK1HIF1AFOLH1PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739055-B2 | Process for preparing diisocyanates based on lysine | EVONIK OPERATIONS GMBH (DE) | 2023-08-29 | — | — | US | disclosed |
| US-8853325-B2 | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120123065-A1 | Hydrolytically Stable Maleimide-Terminated Polymers | NEKTAR THERAPEUTICS (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120065429-A1 | WATER-SOLUBLE POLYMER ALKANALS | NEKTAR THERAPEUTICS (US) | 2012-03-15 | — | — | US | disclosed |
| US-8106131-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS (US) | 2012-01-31 | — | — | US | disclosed |
| US-8076412-B2 | Water-soluble polymer alkanals | NEKTAR THERAPEUTICS (US) | 2011-12-13 | — | — | US | disclosed |
| US-7994272-B2 | Maleamic acid polymer derivatives and their bioconjugates | NEKTAR THERAPEUTICS (US) | 2011-08-09 | — | — | US | disclosed |
| US-20110034737-A1 | Water-Soluble Polymer Alkanals | NEKTAR THERAPEUTICS (US) | 2011-02-10 | — | — | US | disclosed |
| US-7838595-B2 | high purity; storage stability; electrophilically activated polymer derivatives with aldehyde functionality for conjugating to biologically active molecules; drug-polymer conjugate; | NEKTAR THERAPEUTICS (US) | 2010-11-23 | — | — | US | disclosed |
| US-20100113329-A1 | Maleamic Acid Polymer Derivatives and Their Bioconjugates | NEKTAR THERAPEUTICS (US) | 2010-05-06 | — | — | US | disclosed |
| US-7659361-B2 | Maleamic acid polymer derivatives and their bioconjugates | NEKTAR THERAPEUTICS (US) | 2010-02-09 | — | — | US | disclosed |
| US-20090234070-A1 | high purity; storage stability; electrophilically activated polymer derivatives with aldehyde functionality for conjugating to biologically active molecules; drug-polymer conjugate; | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090214472-A1 | Interferon-beta polymer conjugates | ENZON PHARMACEUTICALS INC. (NJ) | 2009-08-27 | — | — | US | disclosed |
| US-20090012241-A1 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739055-B2 | Process for preparing diisocyanates based on lysine | KDM7A, KDM8, JMJD6 | KDM4E 19/4885MAPK1 1917/4885HIF1A 1383/4885 |
| US-20120065429-A1 | WATER-SOLUBLE POLYMER ALKANALS | ALK, ALKBH3, AQP1 | KDM4E 1616/4885MAPK1 3891/4885HIF1A 1407/4885 |
| US-20100113329-A1 | Maleamic Acid Polymer Derivatives and Their Bioconjugates | F13A1, ASS1, PSAT1 | KDM4E 2835/4885MAPK1 4065/4885HIF1A 1688/4885 |
| US-20110034737-A1 | Water-Soluble Polymer Alkanals | ALK, ALKBH3, AQP1 | KDM4E 1616/4885MAPK1 3891/4885HIF1A 1407/4885 |
| US-20090214472-A1 | Interferon-beta polymer conjugates | IFNG, IFNAR1, STING1 | KDM4E 4779/4885MAPK1 4548/4885HIF1A 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.