Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326731 | 0.90 | HTR2C (0.40) | HTR2CMAPTHTTLMNANPC1 | |
| SCHEMBL4328666 | 0.86 | PDE4D (0.39) | PDE4BPDE4DPDE4APDE4CHTR2C | |
| SCHEMBL4326546 | 0.83 | PDE4D (0.59) | PDE4BPDE4DPDE4APDE4CHTR2C | |
| SCHEMBL1301737 | 0.77 | MAOA (0.43) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL13620937 | 0.76 | PDE4D (0.46) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL4465297 | 0.74 | HTR2C (0.40) | HTR2CMAPTHTTLMNANPC1 | |
| SCHEMBL8267950 | 0.73 | KMT2A (0.43) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL4326551 | 0.73 | PDE4D (0.47) | PDE4BPDE4DALDH1A1SMN1; SMN2 | |
| SCHEMBL4755347 | 0.73 | PDE4D (0.69) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL4032324 | 0.73 | PDE4D (0.69) | PDE4BPDE4DPDE4APDE4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |