Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24141857 | 0.92 | KMT2A (0.68) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL12895866 | 0.90 | MAPT (0.55) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL14206802 | 0.87 | NPC1 (0.62) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL418527 | 0.86 | MAPT (0.68) | MAPTKMT2ATDP1MEN1CES2 | |
| SCHEMBL15462343 | 0.85 | MAPT (0.51) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL2742859 | 0.85 | KMT2A (0.64) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL12268652 | 0.85 | MAPT (0.51) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL12268536 | 0.84 | KDM4E (0.58) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL12925837 | 0.84 | KMT2A (0.76) | MAPTKMT2ATDP1MEN1POLB | |
| SCHEMBL14430924 | 0.83 | KMT2A (0.57) | MAPTKMT2AMEN1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | disclosed |