SCHEMBL432893

SCHEMBL432893

N#CC1=Cc2ccccc2OC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.41
NISCH Q9Y2I1 1/20 0.41
NPC1 O15118 5/20 0.40
RAB9A P51151 5/20 0.40
SMN1; SMN2 Q16637 4/20 0.40
MAPT P10636 4/20 0.40
NFKB1 P19838 3/20 0.40
NFKB2 Q00653 3/20 0.40
RELA Q04206 3/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
KDM4E B2RXH2 3/20 0.40
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
PTGS1 P23219 4/20 0.35
PTGS2 P35354 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13051430 0.81 ALOX5 (0.41) ALOX5NISCHNPC1RAB9ASMN1; SMN2
SCHEMBL2006177 0.81 ALOX5 (0.45) ALOX5NISCHNPC1RAB9ASMN1; SMN2
SCHEMBL34471543 0.75 HTR2C (0.31) ALOX5PTGS1PTGS2
SCHEMBL20839736 0.75 MMP12 (0.35) ALOX5NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL20839498 0.75 MMP12 (0.38) NPC1RAB9ASMN1; SMN2MAPTNFKB1
SCHEMBL19054488 0.75 TSHR (0.33)
SCHEMBL9692516 0.75 TLR2 (0.35) ALOX5MAPTMEN1KMT2AKDM4E
SCHEMBL8831274 0.74 ALOX5 (0.40) ALOX5NISCHNPC1RAB9ASMN1; SMN2
SCHEMBL20582126 0.73 KDM4E (0.35) SMN1; SMN2MAPTKMT2AKDM4EMAOA
SCHEMBL545307 0.72 MTNR1A (0.49) ALOX5NPC1RAB9ASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119708027-A Method for preparing boronated carbonyl derivative 中国科学院大连化学物理研究所 2025-03-28 CN claimed
CN-118380656-B Electrolyte and lithium-sulfur battery 蜂巢能源科技股份有限公司 2024-10-22 CN claimed
CN-118380656-A Electrolyte and lithium-sulfur battery 蜂巢能源科技股份有限公司 2024-07-23 CN claimed
CN-116730967-A Synthesis method of chroman-3-formic acid 安徽大学 2023-09-12 CN claimed
US-20120088923-A1 METHOD FOR PREPARING A COUMARIN COMPOUND, CHROMENE COMPOUND, AND METHOD FOR PREPARING A CHROMENE COMPOUND KAOHSIUNG MEDICAL UNIVERSITY (TW) 2012-04-12 US claimed
EP-0184801-B1 CHROMENE DERIVATIVE, PROCESS FOR PREPARING THE SAME AND ANTIALLERGIC AGENT CONTAINING THE SAME Kaken Pharmaceutical Co., Ltd. (JP) 1990-09-26 EP claimed
EP-0184801-A1 Chromene derivative, process for preparing the same and antiallergic agent containing the same Kaken Pharmaceutical Co., Ltd. (JP) 1986-06-18 EP claimed
JP-61137881-A None JP disclosed
EP-4703358-A1 BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF China Pharmaceutical University (CN) 2026-03-04 EP disclosed
WO-2025092775-A1 PHTHALAZINONE GSPT1 PROTEIN DEGRADING AGENT AND USE THEREOF 中国药科大学 2025-05-08 WO disclosed
CN-119912437-A Phthalazinone GSPT protein degradation agent and application thereof 中国药科大学 2025-05-02 CN disclosed
WO-2025034810-A1 SYNTHESES AND USE OF POTASSIUM CHANNEL BLOCKERS IN PET IMAGING AND IN THERAPEUTICS THE GENERAL HOSPITAL CORPORATION (US) 2025-02-13 WO disclosed
WO-2024222918-A1 BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF 中国药科大学 2024-10-31 WO disclosed
WO-1996020296-A1 USE OF CHROMIUM DERIVATIVES AS BRIGHTENERS BASF AKTIENGESELLSCHAFT (DE) 1996-07-04 WO disclosed
US-5112855-A Nootropic Agents CIBA-GEIGY CORPORATION (US) 1992-05-12 US disclosed
EP-0184801-B1 CHROMENE DERIVATIVE, PROCESS FOR PREPARING THE SAME AND ANTIALLERGIC AGENT CONTAINING THE SAME Kaken Pharmaceutical Co., Ltd. (JP) 1990-09-26 EP disclosed
US-4957928-A NOOTROPIC AGENTS, COGNITION ACTIVATORS CIBA-GEIGY CORPORATION (US) 1990-09-18 US disclosed
US-4731375-A Coumarin derivatives and antiallergic agents containing the same KAKEN PHARMACEUTICAL CO., LTD. (JP) 1988-03-15 US disclosed
JP-S61137881-A CHROMENE DERIVATIVE, ITS PREPARATION AND ANTIALLERGIC CONTAINING SAME AS AN ACTIVE INGREDIENT KAKEN PHARMACEUT CO LTD 1986-06-25 JP disclosed
EP-0184801-A1 Chromene derivative, process for preparing the same and antiallergic agent containing the same Kaken Pharmaceutical Co., Ltd. (JP) 1986-06-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120088923-A1 METHOD FOR PREPARING A COUMARIN COMPOUND, CHROMENE COMPOUND, AND METHOD FOR PREPARING A CHROMENE COMPOUND CYP3A7, CYP2A7, F7 ALOX5 1360/4885NISCH 59/4885NPC1 548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.