SCHEMBL4329513

SCHEMBL4329513

CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C.CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)CC)[C@@H](C)O)C(C)C

nearest known ligand 0.78

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
VIPR1 P32241 9/20 0.78
VIPR2 P41587 10/20 0.75
GLP1R P43220 5/20 0.71
ECE1 P42892 1/20 0.71
MUS81 Q96NY9 1/20 0.71
CCKBR P32239 1/20 0.68
PTH1R Q03431 1/20 0.66
NPY2R P49146 2/20 0.66
NPY4R P50391 2/20 0.66
NPY5R Q15761 2/20 0.66
NPY1R P25929 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4331434 0.93 NPY2R (0.75) VIPR1NPY2RNPY4RNPY5RNPY1R
SCHEMBL15669203 0.92 NPY2R (0.74) VIPR1GLP1RNPY2RNPY4RNPY5R
SCHEMBL29569801 0.91 VIPR1 (0.79) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL29389724 0.91 VIPR1 (0.79) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL31060733 0.90 VIPR1 (0.76) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL29382043 0.90 GLP1R (0.80) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL29523535 0.90 VIPR1 (0.69) VIPR1VIPR2GLP1RECE1MUS81
Aviptadil SCHEMBL29357337 0.89 VIPR1 (0.84) VIPR1VIPR2GLP1RECE1MUS81
SCHEMBL31060658 0.89 GLP1R (0.89) VIPR1GLP1RECE1MUS81CCKBR
Glp-1 SCHEMBL29353361 0.89 GLP1R (0.89) VIPR1GLP1RECE1MUS81CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240238382-A1 URI Agonist/Vasodilator LILLY CO ELI (US) 2024-07-18 US disclosed
US-11872266-B2 Rapid-acting insulin compositions ELI LILLY AND COMPANY (US) 2024-01-16 US disclosed
CN-110662551-B Quick acting insulin compositions 伊莱利利公司 2023-07-18 CN disclosed
EP-4169505-A1 RAPID-ACTING INSULIN COMPOSITIONS Eli Lilly and Company (US) 2023-04-26 EP disclosed
CN-115697379-A Quick-acting insulin composition and medical application thereof 江苏恒瑞医药股份有限公司 2023-02-03 CN disclosed
EP-4108253-A1 RAPID-ACTING INSULIN COMPOSITIONS Eli Lilly and Company (US) 2022-12-28 EP disclosed
EP-3233108-B1 RAPID-ACTING INSULIN COMPOSITIONS LILLY CO ELI (US) 2022-03-30 EP disclosed
US-20220072105-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY 2022-03-10 US disclosed
EP-3943155-A1 RAPID-ACTING INSULIN COMPOSITIONS Eli Lilly and Company (US) 2022-01-26 EP disclosed
WO-2022002008-A1 QUICK-ACTING INSULIN COMPOSITION AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2022-01-06 WO disclosed
US-20160166695-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY 2016-06-16 US disclosed
US-20160129087-A1 RAPID-ACTING INSULIN COMPOSITIONS LILLY CO ELI (US) 2016-05-12 US disclosed
WO-2015171484-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY (US) 2015-11-12 WO disclosed
WO-2015165948-A2 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES PHARNEXT (FR) 2015-11-05 WO disclosed
EP-2914252-A1 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL Pharnext (FR) 2015-09-09 EP disclosed
US-20150231123-A1 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL PHARNEXT (FR) 2015-08-20 US disclosed
WO-2015063140-A1 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL PHARNEXT (FR) 2015-05-07 WO disclosed
WO-2014068007-A1 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL PHARNEXT (FR) 2014-05-08 WO disclosed
EP-2021502-A1 NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY Oy Jurilab Ltd (FI) 2009-02-11 EP disclosed
WO-2007128884-A1 NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY OY JURILAB LTD (FI) 2007-11-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240238382-A1 URI Agonist/Vasodilator GPR119, INSR, IAPP VIPR1 204/4885VIPR2 214/4885GLP1R 5/4885
US-20160166695-A1 RAPID-ACTING INSULIN COMPOSITIONS INSR, IAPP, GPR119 VIPR1 1150/4885VIPR2 1456/4885GLP1R 8/4885
US-20160129087-A1 RAPID-ACTING INSULIN COMPOSITIONS INSR, IAPP, GPR119 VIPR1 278/4885VIPR2 422/4885GLP1R 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.