Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380667 | 0.81 | LMNA (0.51) | LMNA | |
| SCHEMBL18489542 | 0.81 | KCNK3 (0.46) | ALDH1A1KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL4330748 | 0.80 | KDM4E (0.62) | ALDH1A1KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL4324944 | 0.79 | NPSR1 (0.46) | — | |
| SCHEMBL29657201 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ALOX15KDM4ELMNACYP1A2 | |
| Benzene SCHEMBL28132022 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ALOX15KDM4ELMNACYP1A2 | |
| SCHEMBL254364 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ALOX15KDM4ELMNACYP1A2 | |
| Hydrogen Peroxide SCHEMBL9514730 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ALOX15KDM4ELMNACYP1A2 | |
| SCHEMBL7831533 | 0.78 | KCNK3 (0.46) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8768064 | 0.78 | SENP1 (0.44) | ALDH1A1KDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312424-A1 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-7576127-B2 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7230003-B2 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060287525-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. | 2006-12-21 | — | — | US | disclosed |
| US-20050107385-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312424-A1 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | CYP2C19, CYP3A5, CYP2C9 | ALDH1A1 3668/4885ALOX15 1086/4885KDM4E 820/4885 |
| US-20050107385-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | CYP2C19, CYP3A5, CYP2C9 | ALDH1A1 3668/4885ALOX15 1086/4885KDM4E 820/4885 |
| US-20060287525-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | CYP2C19, CYP3A5, CYP2C9 | ALDH1A1 3668/4885ALOX15 1086/4885KDM4E 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.