Metrizamide

Metrizamide

SCHEMBL433082

CC(=O)Nc1c(I)c(C(=O)N[C@H]2C(O)O[C@H](CO)[C@@H](O)[C@@H]2O)c(I)c(N(C)C(C)=O)c1I.C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.76
KDM4E B2RXH2 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HK1 P19367 3/20 0.33
HK2 P52789 3/20 0.33
LGALS3 P17931 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metrizamide SCHEMBL16984723 0.87 LMNA (1.00) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL1650311 0.87 LMNA (1.00) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL24382 0.87 LMNA (1.00) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL11048850 0.87 LMNA (1.00) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL24383 0.87 LMNA (1.00) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL8678604 0.87 LMNA (1.00) LMNAKDM4ECYP2D6CYP2C19HK1
Iohexol SCHEMBL28086756 0.80 LMNA (0.73) LMNAKDM4ECYP2D6CYP2C19HK1
Ioversol SCHEMBL7774956 0.78 LMNA (0.69) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL17909957 0.76 LMNA (0.75) LMNAKDM4ECYP2D6CYP2C19HK1
Metrizamide SCHEMBL8373063 0.75 LMNA (0.64) LMNAKDM4ECYP2D6CYP2C19LGALS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160199464-A1 ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE UNIV JOHNS HOPKINS (US) 2016-07-14 US disclosed
US-9220761-B2 Alginate and alginate lyase compositions and methods of use THE JOHN HOPKINS UNIVERSITY (US) 2015-12-29 US disclosed
US-20130211249-A1 DRUG ELUTING HYDROGELS FOR CATHETER DELIVERY THE JOHNS HOPKINS UNIVERSITY (US) 2013-08-15 US disclosed
WO-2012012772-A2 DRUG ELUTING HYDROGELS FOR CATHETER DELIVERY THE JOHNS HOPKINS UNIVERSITY (US) 2012-01-26 WO disclosed
US-20110104052-A1 METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES THE JOHNS HOPKINS UNIVERSITY (US) 2011-05-05 US disclosed
EP-2229147-A2 METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES The Johns Hopkins University (US) 2010-09-22 EP disclosed
US-20100080788-A1 ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE THE JOHNS HOPKINS UNIVERSITY (US) 2010-04-01 US disclosed
EP-2081964-A2 ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE The Johns Hopkins University (US) 2009-07-29 EP disclosed
WO-2009073193-A2 METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES THE JOHNS HOPKINS UNIVERSITY (US) 2009-06-11 WO disclosed
WO-2008127290-A9 ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE UNIV JOHNS HOPKINS (US) 2008-12-24 WO disclosed
WO-2008127290-A2 ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE THE JOHNS HOPKINS UNIVERSITY (US) 2008-10-23 WO disclosed
US-4439613-A Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1984-03-27 US disclosed
US-4341756-A Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1982-07-27 US disclosed