Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16026648 | 0.86 | HRH3 (0.84) | TDP1L3MBTL1HRH3CYP3A4CYP1A2 | |
| SCHEMBL3993675 | 0.82 | HRH3 (0.92) | TDP1L3MBTL1HRH3CYP3A4CYP1A2 | |
| SCHEMBL3993201 | 0.82 | HRH3 (1.00) | TDP1L3MBTL1HRH3CYP3A4CYP1A2 | |
| SCHEMBL6634823 | 0.81 | HRH3 (0.66) | HRH3CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL3994665 | 0.81 | CYP1A2 (1.00) | TDP1L3MBTL1HRH3CYP3A4CYP1A2 | |
| SCHEMBL78043 | 0.81 | SIGMAR1 (0.79) | SIGMAR1POLBMEN1KMT2AMAPT | |
| SCHEMBL9539677 | 0.81 | SIGMAR1 (0.79) | SIGMAR1POLBMEN1KMT2AMAPT | |
| SCHEMBL19631783 | 0.80 | HRH3 (0.54) | TDP1L3MBTL1HRH3CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL11142875 | 0.79 | HRH3 (0.63) | HRH3CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL4172158 | 0.79 | TDP1 (0.72) | TDP1L3MBTL1HRH3CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110136820-A1 | Heterocyclic Compounds as CCR2 Antagonists | ASTRAZENECA AB (SE) | 2011-06-09 | — | — | US | disclosed |
| CN-1764661-B | Benzenesulfonamide derivatives, process for their preparation and their use for the treatment of pain | FOURNIER LAB SA | 2010-05-05 | — | — | CN | disclosed |
| EP-1606288-B1 | BENZENESULPHONAMIDE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATMENT OF PAIN | FOURNIER LAB SA (FR) | 2009-06-03 | — | — | EP | disclosed |
| US-7538111-B2 | Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | LABORATOIRES FOURNIER S.A. (FR) | 2009-05-26 | — | — | US | disclosed |
| US-20060178360-A1 | Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | LABORATOIRES FOURNIER S.A. (FR) | 2006-08-10 | — | — | US | disclosed |
| CN-1764661-A | Benzenesulfonamide derivatives, process for their preparation and their use for the treatment of pain | FOURNIER LAB SA (FR) | 2006-04-26 | — | — | CN | disclosed |
| EP-1606288-A1 | BENZENESULPHONAMIDE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATMENT OF PAIN | LABORATOIRES FOURNIER S.A. (FR) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004087700-A1 | BENZENESULPHONAMIDE DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF FOR TREATMENT OF PAIN | LABORATOIRES FOURNIER S.A. (FR) | 2004-10-14 | — | — | WO | disclosed |
| US-4620033-A | CATALYST OF NICKEL COMPOUND, IODIDE COMPOUND AND PROMOTER OF TIN COMPOUND AND LITHIUM COMPOUND | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4544511-A | CATALYST CONTAINING NICKEL, HALIDES AND ORGANIC NITROGEN COMPOUND;COCATALYST OF METAL COMPOUND | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1985-10-01 | — | — | US | disclosed |
| EP-0065817-B1 | PROCESS FOR PRODUCING CARBOXYLIC ACIDS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1985-07-24 | — | — | EP | disclosed |
| EP-0055622-B1 | PROCESS FOR PRODUCING ACETIC ANHYDRIDE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1985-05-29 | — | — | EP | disclosed |
| EP-0035860-B1 | PROCESS FOR PRODUCING ETHYLIDENE DIACETATE AND/OR ACETALDEHYDE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1984-03-14 | — | — | EP | disclosed |
| EP-0048174-B1 | PROCESS FOR PRODUCING VINYL ACETATE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1984-02-22 | — | — | EP | disclosed |
| EP-0065817-A1 | Process for producing carboxylic acids | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1982-12-01 | — | — | EP | disclosed |
| EP-0055622-A1 | Process for producing acetic anhydride | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1982-07-07 | — | — | EP | disclosed |
| EP-0048174-A1 | Process for producing vinyl acetate | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1982-03-24 | — | — | EP | disclosed |
| EP-0035860-A2 | Process for producing ethylidene diacetate and/or acetaldehyde | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1981-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178360-A1 | Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | LTB4R2, BDKRB2, TBXA2R | TDP1 3724/4885L3MBTL1 4617/4885HRH3 863/4885 |
| US-20110136820-A1 | Heterocyclic Compounds as CCR2 Antagonists | CCR2, CCR3, CXCR2 | TDP1 4844/4885L3MBTL1 2010/4885HRH3 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.