Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321178 | 0.89 | LMNA (0.51) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL4320012 | 0.89 | LMNA (0.46) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL4336046 | 0.88 | LMNA (0.46) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4333849 | 0.87 | DRD2 (0.46) | SMN1; SMN2NAMPTMAPTSIGMAR1DRD2 | |
| SCHEMBL4330789 | 0.87 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2DRD2DRD3 | |
| SCHEMBL4325414 | 0.87 | KMT2A (0.47) | KMT2ANAMPTDRD2DRD3DRD4 | |
| SCHEMBL4340863 | 0.86 | PTAFR (0.42) | NPC1RAB9ASMN1; SMN2DRD2DRD3 | |
| SCHEMBL4324148 | 0.86 | SCN9A (0.46) | NAMPTMAPTSIGMAR1 | |
| SCHEMBL4326354 | 0.84 | NAMPT (0.46) | NAMPTDRD2DRD3 | |
| SCHEMBL4324654 | 0.83 | NPC1 (0.46) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |