Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324148 | 0.90 | SCN9A (0.46) | MAPTTMEM97SIGMAR1SCN9A | |
| SCHEMBL4320012 | 0.90 | LMNA (0.46) | LMNAALDH1A1RAB9ANPC1TMEM97 | |
| SCHEMBL4333849 | 0.88 | DRD2 (0.46) | MAPTSMN1; SMN2TMEM97SIGMAR1DRD2 | |
| SCHEMBL4325414 | 0.88 | KMT2A (0.47) | DRD2DRD3SCN9AKMT2A | |
| SCHEMBL4330789 | 0.88 | NPC1 (0.49) | LMNASMN1; SMN2RAB9ANPC1DRD2 | |
| SCHEMBL4331873 | 0.88 | NPC1 (0.50) | ALDH1A1MAPTSMN1; SMN2HTTRAB9A | |
| SCHEMBL4326354 | 0.85 | NAMPT (0.46) | NR1H4DRD2DRD3SCN9AEPHX2 | |
| SCHEMBL4324654 | 0.84 | NPC1 (0.46) | RAB9ANPC1SCN9A | |
| SCHEMBL4321416 | 0.84 | DRD2 (0.46) | LMNAALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL4326720 | 0.83 | DRD3 (0.47) | LMNARAB9ANPC1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |