Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320012 | 0.90 | LMNA (0.46) | DRD2DRD4DRD3TMEM97CPT2 | |
| SCHEMBL4330789 | 0.89 | NPC1 (0.49) | DRD2DRD4DRD3SMN1; SMN2CPT2 | |
| SCHEMBL4336046 | 0.88 | LMNA (0.46) | DRD2DRD3TMEM97SIGMAR1MAPT | |
| SCHEMBL4324148 | 0.88 | SCN9A (0.46) | TMEM97SIGMAR1MAPTNAMPTSCN9A | |
| SCHEMBL4331873 | 0.87 | NPC1 (0.50) | DRD2DRD4DRD3SIGMAR1MAPT | |
| SCHEMBL4325414 | 0.87 | KMT2A (0.47) | DRD2DRD4DRD3NAMPTSCN9A | |
| SCHEMBL4326354 | 0.86 | NAMPT (0.46) | DRD2DRD3NAMPTCPT2CPT1A | |
| SCHEMBL4326720 | 0.85 | DRD3 (0.47) | DRD2DRD4DRD3NAMPT | |
| SCHEMBL4321416 | 0.84 | DRD2 (0.46) | DRD2DRD4DRD3MAPTSMN1; SMN2 | |
| SCHEMBL4324654 | 0.83 | NPC1 (0.46) | CPT2CPT1ACPT1BSCN9AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |