Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321849 | 0.84 | PARP1 (0.34) | ALDH1A1KDM4EKMT2APARP1ATR | |
| SCHEMBL4332010 | 0.79 | FGFR3 (0.53) | FGFR3ACVRL1ACVR1ALDH1A1HSD17B10 | |
| SCHEMBL12678295 | 0.70 | FGFR3 (0.63) | FGFR3ALDH1A1HSD17B10KDM4EKMT2A | |
| SCHEMBL1126390 | 0.68 | FGFR3 (0.49) | FGFR3ALDH1A1HSD17B10KDM4ECDC7 | |
| SCHEMBL17023016 | 0.65 | FGFR3 (0.49) | FGFR3ACVRL1ACVR1ALDH1A1HSD17B10 | |
| SCHEMBL3318017 | 0.64 | FGFR3 (0.43) | FGFR3ALDH1A1HSD17B10KDM4EKMT2A | |
| SCHEMBL3321225 | 0.63 | JAK2 (0.45) | — | |
| SCHEMBL3318023 | 0.62 | FGFR3 (0.44) | FGFR3ALDH1A1HSD17B10KDM4ECDC7 | |
| Fumaric Acid SCHEMBL3380801 | 0.62 | DRD2 (0.48) | ACVRL1ACVR1ALDH1A1HSD17B10KDM4E | |
| Fumaric Acid SCHEMBL3380807 | 0.62 | DRD2 (0.48) | ACVRL1ACVR1ALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | claimed |