Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321851 | 0.83 | L3MBTL1 (0.39) | FGFR3ALDH1A1L3MBTL1KDM4EHDAC3 | |
| SCHEMBL12678295 | 0.83 | FGFR3 (0.63) | FGFR3ALDH1A1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL1126390 | 0.79 | FGFR3 (0.49) | FGFR3ALDH1A1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL4332007 | 0.79 | FGFR3 (0.43) | FGFR3ALDH1A1HSD17B10ACVRL1ACVR1 | |
| SCHEMBL17023016 | 0.77 | FGFR3 (0.49) | FGFR3ALDH1A1HSD17B10ACVRL1ACVR1 | |
| SCHEMBL3318023 | 0.73 | FGFR3 (0.44) | FGFR3ALDH1A1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL12678289 | 0.70 | FGFR3 (0.74) | FGFR3 | |
| SCHEMBL3318017 | 0.70 | FGFR3 (0.43) | FGFR3ALDH1A1HSD17B10L3MBTL1KDM4E | |
| SCHEMBL1126897 | 0.68 | L3MBTL1 (0.58) | FGFR3ALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL29537043 | 0.68 | GRIN2D (0.55) | ALDH1A1L3MBTL1KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | claimed |