Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4326709 | 0.98 | SLC1A1 (0.47) | SLC1A1TAAR1DPP4DPP7IDO1 | |
| SCHEMBL5230103 | 0.84 | SLC1A1 (0.55) | SLC1A1TAAR1DPP4DPP7IDO1 | |
| SCHEMBL5230112 | 0.84 | SLC1A1 (0.55) | SLC1A1TAAR1DPP4DPP7IDO1 | |
| SCHEMBL7967754 | 0.84 | SLC1A1 (0.55) | SLC1A1TAAR1DPP4DPP7IDO1 | |
| SCHEMBL27505437 | 0.80 | SLC1A1 (0.47) | SLC1A1DPP4DPP7ROCK1 | |
| SCHEMBL3130819 | 0.79 | SLC1A1 (0.50) | SLC1A1TAAR1DPP4DPP7IDO1 | |
| SCHEMBL14478266 | 0.78 | PNMT (0.60) | SLC1A1TAAR1IDO1AGXTHTR2A | |
| SCHEMBL1530031 | 0.78 | PNMT (0.60) | SLC1A1TAAR1IDO1AGXTHTR2A | |
| SCHEMBL29410132 | 0.78 | PNMT (0.60) | SLC1A1TAAR1IDO1AGXTHTR2A | |
| SCHEMBL2561950 | 0.78 | PNMT (0.60) | SLC1A1TAAR1IDO1AGXTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |