Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | FABP2 | P12104 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498892 | 0.90 | FAAH (0.54) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL13704188 | 0.85 | PTGS1 (0.61) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL13704427 | 0.84 | PTGS1 (0.54) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL4330017 | 0.83 | PTGS1 (0.58) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL4330203 | 0.83 | PTGS1 (0.58) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL5319028 | 0.83 | LMNA (0.67) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL5319034 | 0.83 | LMNA (0.67) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL13704164 | 0.83 | PTGS2 (0.70) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL13704171 | 0.82 | AKR1C3 (0.50) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL5322794 | 0.81 | CYP2C19 (0.71) | PTGS1AKR1C3AKR1C2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709155-B1 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | CHESTERFORD ENTPR LTD (KY) | 2013-10-02 | — | — | EP | disclosed |
| US-7585997-B2 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | CHESTERFORD ENTERPRISES LIMITED (KY) | 2009-09-08 | — | — | US | disclosed |
| US-7585997-B2 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | CHESTERFORD ENTERPRISES LIMITED (KY) | 2009-09-08 | — | — | US | disclosed |
| US-20050182134-A1 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | CONVERSANT INTELLECTUAL PROPERTY MANAGEMENT INC. (CA) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182134-A1 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | PYGL, TP53, MKI67 | PTGS1 327/4885AKR1C3 1147/4885AKR1C2 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.