Ethylene Glycol

Ethylene Glycol

SCHEMBL4333640

O=S(=O)(O)c1ccccc1.O=S(=O)(O)c1ccccc1.OCCO

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of Ethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.80
SMN1; SMN2 Q16637 2/20 0.80
POLB P06746 1/20 0.54
CYP2D6 P10635 1/20 0.54
LMNA P02545 2/20 0.48
HTR6 P50406 1/20 0.48
ALDH1A1 P00352 5/20 0.46
NT5E P21589 1/20 0.46
PSIP1 O75475 1/20 0.46
TDP1 Q9NUW8 3/20 0.45
HSD17B10 Q99714 2/20 0.45
NAPRT Q6XQN6 1/20 0.45
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
APOBEC3G Q9HC16 1/20 0.44
MMP1 P03956 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MMP8 P22894 1/20 0.44
MMP13 P45452 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene Glycol SCHEMBL4329926 1.00 TSHR (0.80) TSHRSMN1; SMN2POLBCYP2D6LMNA
1,3-Propanediol SCHEMBL16044212 0.91 TSHR (0.73) TSHRSMN1; SMN2POLBCYP2D6LMNA
1,4-Butanediol SCHEMBL28575010 0.91 TSHR (0.73) TSHRSMN1; SMN2POLBCYP2D6LMNA
SCHEMBL30307036 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA
Benzene SCHEMBL9751882 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA
SCHEMBL3409457 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA
SCHEMBL30812783 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA
SCHEMBL597672 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA
SCHEMBL2509 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA
SCHEMBL30671620 0.89 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994008981-A1 PREPARATION OF ORGANIC MACROCYCLIC COMPOUNDS UNILEVER PLC (GB) 1994-04-28 WO claimed
EP-2969201-B1 NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS FORMOSA PLASTICS CORP USA (US) 2022-05-04 EP disclosed
CN-112334509-A Transesterification process for the simultaneous production of at least two different types of polycarbonate in a production plant 科思创知识产权两合公司 2021-02-05 CN disclosed
CN-107851847-B Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same 中央硝子株式会社 2020-12-18 CN disclosed
US-9790291-B2 Non-phthalate compounds as electron donors for polyolefin catalysts FORMOSA PLASTICS CORPORATION, USA (US) 2017-10-17 US disclosed
US-20140275456-A1 NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS FORMOSA PLASTICS CORPORATION, USA (US) 2014-09-18 US disclosed
US-20090117314-A1 PROCESS FOR THE PREPARATION OF POLYCARBONATE BY THE MELT TRANSESTERIFICATION METHOD BAYER MATERIALSCIENCE AG (DE) 2009-05-07 US disclosed
EP-0602254-B1 POLYMERIZABLE MONOMER, POLYMER THEREOF, AND PROCESS FOR PRODUCING THE SAME OTSUKA KAGAKU KK (JP) 1997-01-02 EP disclosed
US-5326861-A Cyclization LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1994-07-05 US disclosed
EP-0602254-A1 POLYMERIZABLE MONOMER, POLYMER THEREOF, AND PROCESS FOR PRODUCING THE SAME OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1994-06-22 EP disclosed
WO-1994008981-A1 PREPARATION OF ORGANIC MACROCYCLIC COMPOUNDS UNILEVER PLC (GB) 1994-04-28 WO disclosed