Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CCR6 | P51684 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842439 | 0.78 | RECQL (0.44) | RECQLHTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL12604704 | 0.76 | PDGFRB (0.56) | RECQLHTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL27474529 | 0.73 | ALDH1A1 (0.57) | RECQLHTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL4333646 | 0.70 | HTT (0.47) | RECQLHTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL13483711 | 0.70 | TSHR (0.44) | RECQLHTTLMNAALDH1A1HSP90AA1 | |
| SCHEMBL8137115 | 0.70 | TSHR (0.53) | HTTALDH1A1POLBHSP90AA1HPGD | |
| SCHEMBL4333642 | 0.69 | PDGFRB (0.49) | RECQLHTTPDGFRBFGFR1PDGFRA | |
| SCHEMBL8136193 | 0.69 | RECQL (0.44) | RECQLHTTLMNAALDH1A1POLB | |
| SCHEMBL8135018 | 0.69 | LMNA (0.42) | HTTLMNAALDH1A1POLBHPGD | |
| SCHEMBL8135022 | 0.69 | LMNA (0.42) | HTTLMNAALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688803-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |