Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | DTYMK | P23919 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395696 | 0.90 | TSHR (0.56) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL28196295 | 0.90 | TSHR (0.56) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL26841751 | 0.90 | TSHR (0.56) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL11614707 | 0.87 | TSHR (0.49) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL21177993 | 0.87 | TSHR (0.49) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL272650 | 0.86 | TSHR (0.61) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL23699550 | 0.85 | TSHR (0.47) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL16676395 | 0.85 | TSHR (0.47) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL11991419 | 0.85 | TSHR (0.47) | TSHRDTYMKTDP1L3MBTL1CASP6 | |
| SCHEMBL10630877 | 0.85 | TSHR (0.47) | TSHRDTYMKTDP1L3MBTL1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912700-B2 | Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines | PHEON THERAPEUTICS LTD (GB) | 2024-02-27 | — | — | US | disclosed |
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | IMMUNOGEN, INC. (US) | 2023-10-24 | — | — | US | disclosed |
| US-11779663-B2 | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-10-10 | — | — | US | disclosed |
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-10 | — | — | US | disclosed |
| US-11701430-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2023-07-18 | — | — | US | disclosed |
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-07-04 | — | — | US | disclosed |
| US-20180221506-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2018-08-09 | — | — | US | disclosed |
| US-10029018-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2018-07-24 | — | — | US | disclosed |
| US-20180193480-A1 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES | MEDIMMUNE LIMITED (GB) | 2018-07-12 | — | — | US | disclosed |
| US-10017580-B2 | Humanized anti-Tn-MUC1 antibodies and their conjugates | ADC Therpeutics S.A. (CH) | 2018-07-10 | — | — | US | disclosed |
| US-20100273768-A1 | Inhibitors of Bruton's Tyrosine Kinase | DEWDNEY NOLAN JAMES | 2010-10-28 | — | — | US | disclosed |
| WO-2010095678-A1 | FLUORINATED DICARBOXYLIC ACID DERIVATIVE AND POLYMER OBTAINED THEREFROM | セントラル硝子株式会社 (JP) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010084067-A2 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-07-29 | — | — | WO | disclosed |
| US-20100099754-A1 | 5,6-DIMETHYL XANTHONE-4-ACETIC ACID DERIVATIVES AND METHOD OF PREPARING THE SAME | GRAND PHARMA (CHINA) CO., LTD. (CN) | 2010-04-22 | — | — | US | disclosed |
| CN-1724597-A | Phase change inks | XEROX CORP (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1724532-A | Colorant compound | XEROX CORP (US) | 2006-01-25 | — | — | CN | disclosed |
| EP-0760819-B1 | TRICYCLIC DICARBONYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2000-07-19 | — | — | EP | disclosed |
| US-5688803-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0760819-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032205-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11701430-B2 | Pyrrolobenzodiazepines and conjugates thereof | CLTB, CD47, CD79B | TSHR 1414/4885DTYMK 2517/4885TDP1 2667/4885 |
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | CD22, CD2, CD2BP2 | TSHR 1179/4885DTYMK 3315/4885TDP1 2183/4885 |
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | IL2RA, CD4, IL2 | TSHR 870/4885DTYMK 2652/4885TDP1 4513/4885 |
| US-20100099754-A1 | 5,6-DIMETHYL XANTHONE-4-ACETIC ACID DERIVATIVES AND METHOD OF PREPARING THE SAME | HCAR2, HAO2, HK2 | TSHR 742/4885DTYMK 2910/4885TDP1 4185/4885 |
| US-20180221506-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CLTB, CD47, CD79B | TSHR 1414/4885DTYMK 2517/4885TDP1 2667/4885 |
| US-11779663-B2 | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof | SLC25A1, GCDH, FH | TSHR 3303/4885DTYMK 110/4885TDP1 3693/4885 |
| US-10017580-B2 | Humanized anti-Tn-MUC1 antibodies and their conjugates | MUC1, CD44, VIM | TSHR 181/4885DTYMK 1498/4885TDP1 1584/4885 |
| US-20100273768-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | TSHR 1887/4885DTYMK 574/4885TDP1 291/4885 |
| US-11912700-B2 | Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines | MKI67, CCND2, CCND1 | TSHR 2641/4885DTYMK 1654/4885TDP1 943/4885 |
| US-10029018-B2 | Pyrrolobenzodiazepines and conjugates thereof | DBH, DDO, DOHH | TSHR 2273/4885DTYMK 3994/4885TDP1 3544/4885 |
| US-20180193480-A1 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES | IL2RA, CD4, IL2 | TSHR 870/4885DTYMK 2652/4885TDP1 4513/4885 |
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | MKI67, GABBR1, GABBR2 | TSHR 879/4885DTYMK 2746/4885TDP1 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.