Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC18A2 | Q05940 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452789 | 0.86 | PKM (0.50) | MAOAMAOBSLC6A4PKMCYP3A4 | |
| SCHEMBL4320735 | 0.86 | MAOA (0.39) | MAOAMAOBSLC6A4PKMCYP3A4 | |
| SCHEMBL4328800 | 0.84 | SLC6A4 (0.38) | MAOAMAOBSLC6A4PKMCYP3A4 | |
| SCHEMBL4459145 | 0.84 | PKM (0.43) | MAOAMAOBSLC6A4PKMCYP3A4 | |
| SCHEMBL4462738 | 0.84 | MAOA (0.38) | MAOAMAOBSLC6A4PKMCYP3A4 | |
| SCHEMBL4328719 | 0.83 | SLC6A4 (0.49) | SLC6A4 | |
| SCHEMBL4338581 | 0.83 | MAOA (0.38) | MAOAMAOBSLC6A4PKMCYP3A4 | |
| SCHEMBL4469056 | 0.77 | CYP3A4 (0.31) | CYP3A4CYP2D6 | |
| SCHEMBL4333706 | 0.77 | SLC6A2 (0.44) | SLC6A4 | |
| SCHEMBL10955829 | 0.72 | MAOA (0.50) | MAOAMAOBSLC6A4BRD4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118765-A2 | NOVEL MONOAMINE RE-UPTAKE INHIBITOR | PANACEA BIOTEC LIMITED (GB) | 2009-10-01 | — | — | WO | disclosed |