Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452789 | 0.87 | PKM (0.50) | PKMMAOAMAOBSLC6A4KDM4E | |
| SCHEMBL4462738 | 0.85 | MAOA (0.38) | PKMMAOAMAOBSLC6A4KDM4E | |
| SCHEMBL4328800 | 0.85 | SLC6A4 (0.38) | PKMMAOAMAOBSLC6A4KDM4E | |
| SCHEMBL4333697 | 0.84 | MAOA (0.40) | PKMMAOAMAOBSLC6A4KDM4E | |
| SCHEMBL4338581 | 0.84 | MAOA (0.38) | PKMMAOAMAOBSLC6A4KDM4E | |
| SCHEMBL4338598 | 0.83 | SLC6A4 (0.50) | SLC6A4HTR2C | |
| SCHEMBL4320735 | 0.82 | MAOA (0.39) | PKMMAOAMAOBSLC6A4KDM4E | |
| SCHEMBL4460770 | 0.76 | SLC6A2 (0.46) | SLC6A4 | |
| SCHEMBL10955829 | 0.73 | MAOA (0.50) | MAOAMAOBSLC6A4CYP3A4CYP2D6 | |
| SCHEMBL4457705 | 0.72 | MAOA (0.34) | PKMMAOAMAOBSLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118765-A2 | NOVEL MONOAMINE RE-UPTAKE INHIBITOR | PANACEA BIOTEC LIMITED (GB) | 2009-10-01 | — | — | WO | disclosed |