Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13577951 | 0.92 | NR4A2 (0.38) | APPPTGS2CNR2HTR3AHTR1A | |
| SCHEMBL4327173 | 0.90 | SCN9A (0.39) | APPPTGS2CNR2HTR1ADRD2 | |
| SCHEMBL4338927 | 0.80 | LMNA (0.43) | HDAC1HDAC6HDAC3 | |
| SCHEMBL4325414 | 0.79 | KMT2A (0.47) | HTR1ADRD2DRD1DRD4DRD5 | |
| SCHEMBL4336015 | 0.79 | NPC1 (0.41) | PTGS2CNR2SMYD2 | |
| SCHEMBL4321416 | 0.74 | DRD2 (0.46) | DRD2DRD4DRD3HDAC6 | |
| SCHEMBL4333764 | 0.73 | LMNA (0.42) | HDAC1HDAC6HDAC3NR4A2 | |
| SCHEMBL4335709 | 0.71 | CYP2C19 (0.39) | CNR2DRD2DRD4DRD3SMYD2 | |
| SCHEMBL4320012 | 0.71 | LMNA (0.46) | DRD2DRD4DRD3SMYD2 | |
| SCHEMBL4319190 | 0.71 | SLC22A12 (0.43) | CNR2HDAC1HDAC6SMYD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |