Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320012 | 0.89 | LMNA (0.46) | NPC1RAB9ASMYD2SCN9ACPT2 | |
| SCHEMBL4327173 | 0.89 | SCN9A (0.39) | PTGS2SMYD2SCN9AS1PR1CPT2 | |
| SCHEMBL4331918 | 0.83 | BRD4 (0.44) | SMYD2SCN9ACPT2CPT1ACPT1B | |
| SCHEMBL4319190 | 0.82 | SLC22A12 (0.43) | SMYD2SCN9AS1PR1CPT2CPT1A | |
| SCHEMBL4324558 | 0.82 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2SMYD2SCN9A | |
| SCHEMBL4321178 | 0.82 | LMNA (0.51) | NPC1RAB9ALMNAHTTALDH1A1 | |
| SCHEMBL4326354 | 0.81 | NAMPT (0.46) | SMYD2SCN9ACPT2CPT1ACPT1B | |
| SCHEMBL4336046 | 0.81 | LMNA (0.46) | NPC1RAB9ASMN1; SMN2SCN9ALMNA | |
| SCHEMBL4324640 | 0.81 | HCRTR1 (0.54) | RAB9ASMN1; SMN2SCN9AKDM4EALDH1A1 | |
| SCHEMBL4333849 | 0.81 | DRD2 (0.46) | SMN1; SMN2SCN9ACPT2CPT1ACPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |