Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 7/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | BRAF | P15056 | 4/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330508 | 0.92 | MEN1 (0.43) | ALDH1A1LMNAKMT2AMEN1GSK3B | |
| SCHEMBL4327197 | 0.90 | MEN1 (0.43) | ALDH1A1LMNAKMT2AMEN1GSK3B | |
| SCHEMBL4328757 | 0.89 | MEN1 (0.42) | ALDH1A1LMNAKMT2AMEN1GSK3B | |
| SCHEMBL3554660 | 0.89 | KDR (0.50) | ALDH1A1LMNAGSK3BDYRK1AKDR | |
| SCHEMBL27648404 | 0.87 | MEN1 (0.42) | ALDH1A1LMNAKMT2AMEN1GSK3B | |
| SCHEMBL27648402 | 0.87 | MEN1 (0.42) | ALDH1A1LMNAKMT2AMEN1GSK3B | |
| SCHEMBL4330800 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNAKMT2AMEN1GSK3B | |
| SCHEMBL4330137 | 0.86 | GSK3B (0.49) | GSK3BDYRK1AWNT1KDRBRAF | |
| SCHEMBL4328106 | 0.84 | GSK3B (0.48) | GSK3BDYRK1AWNT1KDRBRAF | |
| SCHEMBL4321854 | 0.82 | GCK (0.49) | ALDH1A1KMT2AMEN1KDRGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719762-B1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (1) | EISAI R&D MAN CO LTD (JP) | 2012-06-27 | — | — | EP | disclosed |
| US-7531532-B2 | Hepatocyte growth factor receptor inhibitors; Antitumor agents, anticarcinogenic agents, angiogenesis inhibitors; pyrimidine derivatives like Pyrrolidine-1-carboxylic acid [6-(2-fluoro-4-{3-[2-(4-fluorophenyl)acetyl]thioureido}phenoxy)pyrimidin-4-yl]amide | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-05-12 | — | — | US | disclosed |
| US-20070270421-A1 | Novel pyridine Derivative and Pyrimidine Derivative (1) | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-11-22 | — | — | US | disclosed |
| EP-1719763-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (2) | Eisai Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |
| EP-1719762-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (1) | Eisai Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |
| US-20050277652-A1 | Novel pyridine derivative and pyrimidine derivative | EISAI CO., LTD. (JP) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270421-A1 | Novel pyridine Derivative and Pyrimidine Derivative (1) | HGF, MET, FLT1 | ALDH1A1 557/4885LMNA 4875/4885KMT2A 4095/4885 |
| US-20050277652-A1 | Novel pyridine derivative and pyrimidine derivative | HGF, MET, HDGF | ALDH1A1 930/4885LMNA 4870/4885KMT2A 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.