Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 15/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 15/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325606 | 0.88 | OPRM1 (0.35) | OPRM1OPRD1OPRK1OPRL1PDE3B | |
| SCHEMBL4324388 | 0.86 | OPRM1 (0.34) | OPRM1OPRD1OPRK1OPRL1CYP3A4 | |
| SCHEMBL4318607 | 0.80 | OPRL1 (0.34) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4319335 | 0.79 | MEN1 (0.36) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL4318374 | 0.76 | OPRL1 (0.36) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4334663 | 0.76 | HTR1A (0.33) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4329857 | 0.76 | HTR1A (0.33) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4324416 | 0.75 | OPRM1 (0.66) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4339366 | 0.74 | OPRK1 (0.49) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL12701561 | 0.73 | PDE3B (0.43) | OPRM1OPRD1OPRK1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | GRIN1, GRM1, GRIN3A | OPRM1 264/4885OPRD1 178/4885OPRK1 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.